ArticleJournal of molecular neuroscience : MN1998
Changes in AMPA receptor-spliced variant expression and shift in AMPA receptor spontaneous desensitization pharmacology during cerebellar granule cell maturation in vitro.
Article in Journal of molecular neuroscience : MN, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- GluA2 is rapidly edited at the Q/R site during neural differentiation in vitro.Frontiers in cellular neuroscience · 2015Article
- Models of calcium dynamics in cerebellar granule cells.Cerebellum (London, England) · 2012Review
- Acute neuregulin-1 signaling influences AMPA receptor mediated responses in cultured cerebellar granule neurons.Brain research bulletin · 2012Article
- A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009).Pharmacological research · 2011Review
- Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains.Journal of neuroscience research · 2010Article
- Presynaptic AMPA and kainate receptors increase the size of GABAergic terminals and enhance GABA release.Neuropharmacology · 2007Article
- Stargazin controls the pharmacology of AMPA receptor potentiators.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Reelin secretion from glutamatergic neurons in culture is independent from neurotransmitter regulation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- AMPA prevents glutamate-induced neurotoxicity and apoptosis in cultured cerebellar granule cell neurons.Neurotoxicity research · 2000Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Using appropriate internal standards, quantitative reverse transcripase-polymerase chain reaction (RT-PCR), and cerebellar granule cell (CG) in primary cultures we have quantified the expression of mRNAs encoding for GluR1-4 DL-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunits during neuronal maturation in vitro. GluR1 is the mRNA that increases during CG maturation; the expression changes of the other GluR mRNAs are minimal and the translation products of these mRNAs change with a similar pattern. During CG maturation, there is an 8- to 10-fold increase in the GluR1 FLOP mRNA and a twofold increase in the expression of FLOP mRNA for GluR4 and GluR4C. The GluR1 FLIP mRNA increases, but by a smaller extent. We found that the GluR2 mRNA is completely edited at its Q/R site during CG maturation. The increase on the expression of GluR1 FLIP and FLOP and of GluR4 FLOP mRNA variants during development is associated with a 10-fold increase in AMPA-mediated Na+ currents and in the increased amplification of this current by 7-chloro-3-methyl-3,4 dihydro-2H-1,2,4 benzothiadiazine S-S-dioxide (IDRA21) or by 6-chloro-3,4 dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1 dioxide (cyclothiazide [CT]).
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