ArticleProceedings of the National Academy of Sciences of the United States of America1998
Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Extracellular vesicle signatures from eye lavage as novel non-invasive biomarkers for hypoxic ischaemic insult-findings from a neonatal mouse model.Frontiers in medical technology · 2025Article
- Marcks overexpression in retinal ganglion cells promotes optic nerve regeneration.Cell death & disease · 2024Article
- Role for the PIPJournal of cell communication and signaling · 2024Review
- The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function.Autoimmunity reviews · 2021Review
- Transgenic modeling of Ndr2 gene amplification reveals disturbance of hippocampus circuitry and function.iScience · 2021Article
- Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice.BMC neuroscience · 2017Article
- α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions.International journal of molecular sciences · 2016Review
- X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease.Frontiers in cellular neuroscience · 2015Review
- Lipid dynamics at dendritic spines.Frontiers in neuroanatomy · 2014Review
- Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS.Nature neuroscience · 2013Article
- Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane.The Journal of biological chemistry · 2013Article
- Neuroprotective effects of new protein kinase C activator TPPB against Aβ₂₅₋₃₅ induced neurotoxicity in PC12 cells.Neurochemical research · 2012Article
- Genotype-phenotype correlation in interstitial 6q deletions: a report of 12 new cases.Neurogenetics · 2012Article
- beta-Phorbol ester-induced enhancement of exocytosis in large mossy fiber boutons of mouse hippocampus.The journal of physiological sciences : JPS · 2009Article
- Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide.The Journal of pharmacology and experimental therapeutics · 2008Article
- Performance of PAC1-R heterozygous mice in memory tasks-II.Journal of molecular neuroscience : MN · 2008Article
- Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching.Molecular biology of the cell · 2008Article
- Different forms of MARCKS protein are involved in memory formation in the learning process of imprinting.Experimental brain research · 2008Article
- Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation.Hippocampus · 2006Article
- Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks.Molecular psychiatry · 2003Review
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7 authors.
Funding
Abstract
The myristoylated alanine-rich C kinase substrate (MARCKS) is a prominent protein kinase C (PKC) substrate in brain that is expressed highly in hippocampal granule cells and their axons, the mossy fibers. Here, we examined hippocampal infrapyramidal mossy fiber (IP-MF) limb length and spatial learning in heterozygous Macs mutant mice that exhibit an approximately 50% reduction in MARCKS expression relative to wild-type controls. On a 129B6(N3) background, the Macs mutation produced IP-MF hyperplasia, a significant increase in hippocampal PKCepsilon expression, and proficient spatial learning relative to wild-type controls. However, wild-type 129B6(N3) mice exhibited phenotypic characteristics resembling inbred 129Sv mice, including IP-MF hypoplasia relative to inbred C57BL/6J mice and impaired spatial-reversal learning, suggesting a significant contribution of 129Sv background genes to wild-type and possibly mutant phenotypes. Indeed, when these mice were backcrossed with inbred C57BL/6J mice for nine generations to reduce 129Sv background genes, the Macs mutation did not effect IP-MF length or hippocampal PKCepsilon expression and impaired spatial learning relative to wild-type controls, which now showed proficient spatial learning. Moreover, in a different strain (B6SJL(N1), the Macs mutation also produced a significant impairment in spatial learning that was reversed by transgenic expression of MARCKS. Collectively, these data indicate that the heterozygous Macs mutation modifies the expression of linked 129Sv gene(s), affecting hippocampal mossy fiber development and spatial learning performance, and that MARCKS plays a significant role in spatial learning processes.
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