ArticleProceedings of the National Academy of Sciences of the United States of America1998
In vivo antagonism of a T cell response by an endogenously expressed ligand.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity.Cell · 2025Article
- Signals that control MAIT cell function in healthy and inflamed human tissues.Immunological reviews · 2024Review
- Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity.PLoS pathogens · 2016Article
- Article
- An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4.The Journal of experimental medicine · 2005Article
- Functional reprogramming of the primary immune response by T cell receptor antagonism.The Journal of experimental medicine · 2004Article
- Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides.The Journal of experimental medicine · 2001Article
- Review
- T cell-mediated antigen presentation: a potential mechanism of infectious tolerance.Immunologic research · 2001Review
- H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.The Journal of experimental medicine · 2000Article
- Selective expansion of cross-reactive CD8(+) memory T cells by viral variants.The Journal of experimental medicine · 1999Article
- Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts.Immunity · 1999Article
- A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex.The Journal of experimental medicine · 1999Article
- T cell receptor antagonism in vivo, at last.Proceedings of the National Academy of Sciences of the United States of America · 1998Review
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3 authors.
Funding
Abstract
3.L2 T cell receptor transgenic T cells are activated by the 64-76 peptide of the mouse hemoglobin d beta chain [Hb(64-76)], and their response is antagonized by the position 72 alanine substitution of this peptide (A72). To test the effect of this altered peptide ligand (APL) on 3.L2 T cell function in vivo, a transgene expressing A72 in major histocompatibility complex II positive cells (A72tg) has been introduced into mice. We demonstrate that 3.L2 T cells, when transferred to A72tg+ mice show a dramatically reduced proliferative response to Hb(64-76). Identical decreased responses were observed using T cells that developed in either A72tg+ or A72tg- hosts. This affect was not attributable to diminished precursor frequency, anergy, or competition for binding to I-Ek molecules. These results unequivocally demonstrate in vivo antagonism by an endogenous APL and characterize a class of self-peptides that, although inefficient in causing deletion in the thymus, effectively modulate T cell responses in the periphery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.