ArticleProceedings of the National Academy of Sciences of the United States of America1998
The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- De novo transcriptomic analysis of the alimentary tract of the tephritid gall fly, Procecidochares utilis.PloS one · 2018Article
- Identification and characterization of an Apis cerana cerana Delta class glutathione S-transferase gene (AccGSTD) in response to thermal stress.Die Naturwissenschaften · 2013Article
- Article
- Article
- Alternative splicing generates multiple transcripts of the inhibitor of apoptosis protein 1 in Aedes and Culex spp. mosquitoes.Insect biochemistry and molecular biology · 2007Article
- Differences in the subunit interface residues of alternatively spliced glutathione transferases affects catalytic and structural functions.The Biochemical journal · 2007Article
- Tissue and life stage specificity of glutathione S-transferase expression in the Hessian fly, Mayetiola destructor: implications for resistance to host allelochemicals.Journal of insect science (Online) · 2007Article
- Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme.The Biochemical journal · 2005Article
- Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stress.The Biochemical journal · 2005Article
- The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profiles.BMC genomics · 2003Article
- A sensitive core region in the structure of glutathione S-transferases.The Biochemical journal · 2003Article
- Probing the diversity of the Arabidopsis glutathione S-transferase gene family.Plant molecular biology · 2002Article
- Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.The Biochemical journal · 2001Review
- Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae.The Biochemical journal · 2001Article
- Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens.The Biochemical journal · 2001Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The class I glutathione S-transferases (GSTs) of Anopheles gambiae are encoded by a complex gene family. We describe the genomic organization of three members of this family, which are sequentially arranged on the chromosome in divergent orientations. One of these genes, aggst1-2, is intronless and has been described. In contrast, the two A. gambiae GST genes (aggst1alpha and aggst1beta) reported within are interrupted by introns. The gene aggst1alpha contains five coding exons that are alternatively spliced to produce four mature GST transcripts, each of which contains a common 5' exon encoding the N termini of the GST protein spliced to one of four distinct 3' exons encoding the carboxyl termini. All four of the alternative transcripts of aggst1alpha are expressed in A. gambiae larvae, pupae, and adults. We report on the involvement of alternative RNA splicing in generating multiple functional GST transcripts. A cDNA from the aggst1beta gene was detected in adult mosquitoes, demonstrating that this GST gene is actively transcribed. The percentage similarity of the six cDNAs transcribed from the three GST genes range from 49.5% to 83.1% at the nucleotide level.
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