ArticleProceedings of the National Academy of Sciences of the United States of America1998
An essential role of phosphatidylinositol 3-kinase in myogenic differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- The Self-Assembling Peptide PJournal of functional biomaterials · 2026Article
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- 2-D08 treatment regulates C2C12 myoblast proliferation and differentiation via the Erk1/2 and proteasome signaling pathways.Journal of muscle research and cell motility · 2021Article
- Inhibition of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Hampers the Vasopressin-dependent Stimulation of Myogenic Differentiation.International journal of molecular sciences · 2019Article
- Adverse effects of acrolein, a ubiquitous environmental toxicant, on muscle regeneration and mass.Journal of cachexia, sarcopenia and muscle · 2019Article
- Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.Cancer cell · 2018Article
- MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma.Science translational medicine · 2018Article
- Dynamic transcriptomic analysis in hircine longissimus dorsi muscle from fetal to neonatal development stages.Functional & integrative genomics · 2018Article
- Article
- Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis.Molecular and cellular biology · 2015Article
- Activated Integrin-Linked Kinase Negatively Regulates Muscle Cell Enhancement Factor 2C in C2C12 Cells.BioMed research international · 2015Article
- Article
- Akt-mediated phosphorylation controls the activity of the Y-box protein MSY3 in skeletal muscle.Skeletal muscle · 2015Article
- Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation.The Journal of biological chemistry · 2012Article
- AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell.Cell cycle (Georgetown, Tex.) · 2012Article
- O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling.Molecular and cellular biology · 2012Article
- Caspase-3, myogenic transcription factors and cell cycle inhibitors are regulated by leukemia inhibitory factor to mediate inhibition of myogenic differentiation.Skeletal muscle · 2011Article
- Biphasic regulation of intracellular calcium by gemfibrozil contributes to inhibiting L6 myoblast differentiation: implications for clinical myotoxicity.Chemical research in toxicology · 2011Article
- MicroRNAs in skeletal myogenesis.Cell cycle (Georgetown, Tex.) · 2011Review
- A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The oncogene p3k, coding for a constitutively active form of phosphatidylinositol 3-kinase (PI 3-kinase; EC 2.7.1.137), strongly enhances myogenic differentiation in cultures of chicken-embryo myoblasts. It increases the size of the myotubes and induces elevated levels of the muscle-specific proteins MyoD, myosin heavy chain, creatine kinase, and desmin. Inhibition of PI 3-kinase activity with LY294002 or with dominant-negative mutants of PI 3-kinase interferes with myogenic differentiation and with the induction of muscle-specific genes. PI 3-kinase is therefore an upstream mediator for the expression of the muscle-specific genes and is both necessary and rate-limiting for the process of myogenesis.
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Registered trials
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