ArticleProceedings of the National Academy of Sciences of the United States of America1998
Transgenic cattle produced by reverse-transcribed gene transfer in oocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 182 citations in OpenAlex.
- Outlook on genome editing application to cattle.Journal of veterinary science · 2024Review
- Perspectives in Genome-Editing Techniques for Livestock.Animals : an open access journal from MDPI · 2023Review
- Cows as Bioreactors for the Production of Nutritionally and Biomedically Significant Proteins.Advances in experimental medicine and biology · 2022Article
- The contribution of bovines to human health against viral infections.Environmental science and pollution research international · 2021Review
- Assisted Reproductive Techniques and Genetic Manipulation in the Common Marmoset.ILAR journal · 2020Review
- Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation ofInternational journal of molecular sciences · 2020Article
- Directions and applications of CRISPR technology in livestock research.Animal reproduction · 2018Article
- Efficient Generation of Transgenic Buffalos (Bubalus bubalis) by Nuclear Transfer of Fetal Fibroblasts Expressing Enhanced Green Fluorescent Protein.Scientific reports · 2018Article
- Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors.OncoTargets and therapy · 2018Article
- Crotamine, a cell-penetrating peptide, is able to translocate parthenogenetic and in vitro fertilized bovine embryos but does not improve exogenous DNA expression.Journal of assisted reproduction and genetics · 2016Article
- Gene targeting, genome editing: from Dolly to editors.Transgenic research · 2016Review
- The Effects of GH Transgenic Goats on the Microflora of the Intestine, Feces and Surrounding Soil.PloS one · 2015Article
- Birth of healthy offspring following ICSI in in vitro-matured common marmoset (Callithrix jacchus) oocytes.PloS one · 2014Article
- The presence of HBV mRNA in the fertilized in vitro embryo of HBV patients confirms vertical transmission of HBV via the ovum.Epidemiology and infection · 2013Article
- Progress and prospects for genetic modification of nonhuman primate models in biomedical research.ILAR journal · 2013Review
- Precision editing of large animal genomes.Advances in genetics · 2012Review
- Non-homologous end joining plays a key role in transgene concatemer formation in transgenic zebrafish embryos.International journal of biological sciences · 2010Article
- Quantitative analysis of lentiviral transgene expression in mice over seven generations.Transgenic research · 2010Article
- Generation of transgenic monkeys with human inherited genetic disease.Methods (San Diego, Calif.) · 2009Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A critical requirement for integration of retroviruses, other than HIV and possibly related lentiviruses, is the breakdown of the nuclear envelope during mitosis. Nuclear envelope breakdown occurs during mitotic M-phase, the envelope reforming immediately after cell division, thereby permitting the translocation of the retroviral preintegration complex into the nucleus and enabling integration to proceed. In the oocyte, during metaphase II (MII) of the second meiosis, the nuclear envelope is also absent and the oocyte remains in MII arrest for a much longer period of time compared with M-phase in a somatic cell. Pseudotyped replication-defective retroviral vector was injected into the perivitelline space of bovine oocytes during MII. We show that reverse-transcribed gene transfer can take place in an oocyte in MII arrest of meiosis, leading to production of offspring, the majority of which are transgenic. We discuss the implications of this mechanism both as a means of production of transgenic livestock and as a model for naturally occurring recursive transgenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.