ArticleBiophysical journal1998
Possible cooperation of differential adhesion and chemotaxis in mound formation of Dictyostelium.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Interplay of mesoscale physics and agent-like behaviors in the parallel evolution of aggregative multicellularity.EvoDevo · 2020Review
- Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Genetic control of morphogenesis in Dictyostelium.Developmental biology · 2015Review
- Role of differential adhesion in cell cluster evolution: from vasculogenesis to cancer metastasis.Computer methods in biomechanics and biomedical engineering · 2015Article
- Differential adhesion between moving particles as a mechanism for the evolution of social groups.PLoS computational biology · 2014Article
- Article
- The green tea catechin epigallocatechin gallate (EGCG) blocks cell motility, chemotaxis and development in Dictyostelium discoideum.PloS one · 2013Article
- Cell type-specific filamin complex regulation by a novel class of HECT ubiquitin ligase is required for normal cell motility and patterning.Development (Cambridge, England) · 2011Article
- Phospholipase D controls Dictyostelium development by regulating G protein signaling.Cellular signalling · 2011Article
- Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.Cold Spring Harbor perspectives in biology · 2009Review
- Stochastic collective movement of cells and fingering morphology: no maverick cells.Biophysical journal · 2009Article
- Multicell simulations of development and disease using the CompuCell3D simulation environment.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Growth based morphogenesis of vertebrate limb bud.Bulletin of mathematical biology · 2008Article
- A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis.Biophysical journal · 2007Article
- Directed cell migration in the presence of obstacles.Theoretical biology & medical modelling · 2007Article
- Moving forward moving backward: directional sorting of chemotactic cells due to size and adhesion differences.PLoS computational biology · 2006Article
- A multiscale model for avascular tumor growth.Biophysical journal · 2005Article
- On multiscale approaches to three-dimensional modelling of morphogenesis.Journal of the Royal Society, Interface · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mound stage of Dictyostelium discoideum, pre-stalk cells sort and form a tip at the apex. How this pattern forms is as yet unknown. A cellular level model allows us to simulate both differential cell adhesion and chemotaxis, to show that with differential adhesion only, pre-stalk cells move to the surface of the mound but form no tip. With chemotaxis driven by an outgoing circular wave only, a tip forms but contains both pre-stalk and pre-spore cells. Only for a narrow range of relative strengths between differential adhesion and chemotaxis can both mechanisms work in concert to form a tip containing only pre-stalk cells. The simulations provide a method to determine the processes necessary for patterning and suggest a series of further experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.