ArticleInfection and immunity1998
Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01617083 (Antibiotic Treatment Trial for the PANDAS/PANS Phenotype), which is not on this map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antibiotic Treatment Trial for the PANDAS/PANS Phenotype
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 341 citations in OpenAlex.
- Probiotics as additives on therapy in allergic airway diseases: a systematic review of benefits and risks.BioMed research international · 2013Pooled it
- Childhood allergy is preceded by an absence of gut lactobacilli species and higher levels of atopy-related plasma chemokines.Clinical and experimental immunology · 2020Trial
- Daily Intake of Fermented Milk ContainingNutrients · 2019Trial
- Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults.World journal of gastroenterology · 2008Trial
- Preliminary evidence of the efficacy of probiotic eye-drop treatment in patients with vernal keratoconjunctivitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2008Trial
- Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota.Clinical and experimental immunology · 2006Trial
- Lactobacillus GG in inducing and maintaining remission of Crohn's disease.BMC gastroenterology · 2004Trial
- Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes.Journal of clinical immunology · 2001Trial
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- Oral and gastric microbiome in relation to gastric intestinal metaplasia.International journal of cancer · 2022Article
- Irradiated Non-replicative Lactic Acid Bacteria Preserve Metabolic Activity While Exhibiting Diverse Immune Modulation.Frontiers in veterinary science · 2022Article
- Peanut oral immunotherapy: current trends in clinical trials.Immunotherapy advances · 2022Review
- Transcriptome analysis of Lactobacillus rhamnosus GG strain treated with prebiotic - bovine lactoferrin under a cold environment.Journal of food and drug analysis · 2021Article
- In Vitro Anti-staphylococcal and Anti-inflammatory Abilities of Lacticaseibacillus rhamnosus from Infant Gut Microbiota as Potential Probiotic Against Infectious Women Mastitis.Probiotics and antimicrobial proteins · 2021Article
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- Shaoyao-Gancao Decoction Ameliorates the Inflammation State in Polycystic Ovary Syndrome Rats via Remodeling Gut Microbiota and Suppressing the TLR4/NF-κB Pathway.Frontiers in pharmacology · 2021Article
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- Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human peripheral blood mononuclear cells (PBMC) were stimulated with three nonpathogenic Lactobacillus strains and with one pathogenic Streptococcus pyogenes strain, and cytokine gene expression and protein production were analyzed. All bacteria strongly induced interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha mRNA expression and protein production. S. pyogenes was the most potent inducer of secretion of IL-12 and gamma interferon (IFN-gamma), and two of three Lactobacillus strains induced IL-12 and IFN-gamma production. All strains induced IL-18 protein production. IL-10 and IL-4 production was induced weakly and not at all, respectively. Our data show that nonpathogenic lactobacilli and pathogenic streptococci can induce Th1 type cytokines IL-12, IL-18, and IFN-gamma in human PBMC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.