Evidence map›Paper›PMID 9826391›Full record

ArticleInfection and immunity1998

Contrasting roles of mannan-specific monoclonal immunoglobulin M antibodies in the activation of classical and alternative pathways by Candida albicans.

M X Zhang, J E Cutler, Y Han, T R Kozel

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M X ZhangDepartment of Microbiology and the Cell and Molecular Biology Program, School of Medicine, University of Nevada, Reno, Nevada 89557, USA. mzhang@med.unr.edu
J E Cutler
Y Han
T R Kozel
Montana State University · USUniversity of Nevada, Reno · US

Funding

PHOSPHOMANNOPROTEIN ADHESIN AS A VACCINE CANDIDATEP01AI037194 · NIAID · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI EDWARDS, JOHN E. · 1995 to 2003
$3.6M
CANDIDA ALBICANS SURFACE ANTIGENSR01AI024912 · NIAID · MONTANA STATE UNIVERSITY (BOZEMAN) · PI CUTLER, JIM E. · 1988 to 2006
$2.0M
Cryptococcal polysaccharide-phagocytosis inhibitionR01AI014209 · NIAID · UNIVERSITY OF NEVADA RENO · PI KOZEL, THOMAS R · 1985 to 2009
$1.9M
CRYPTOCOCCAL POLYSACCHARIDE--PHAGOCYTOSIS INHIBITIONR37AI014209 · NIAID · UNIVERSITY OF NEVADA RENO · PI KOZEL, THOMAS R · 1995 to 2004
$1.5M
NIAID NIH HHS AI 14209NIAID NIH HHS AI 24912NIAID NIH HHS AI 37194NIAID NIH HHS P01 AI037194NIAID NIH HHS R01 AI014209NIAID NIH HHS R01 AI024912NIAID NIH HHS R37 AI014209
6 · The paper itself

Abstract

Polyclonal antimannan immunoglobulin G (IgG) activates the classical complement pathway and accelerates initiation of the alternative pathway by Canidida albicans. This dual role was assessed for two antimannan IgM monoclonal antibodies (MAbs). MAb B6.1 is specific for an epitope on the acid-labile portion of C. albicans phosphomannan; MAb B6 is specific for an epitope on the acid-stable region. Both MAbs were potent activators of the classical pathway but poor facilitators of alternative pathway initiation.

Indexed as

Complement ActivationImmunoglobulin MAntibodies, MonoclonalAntibody SpecificityCandida albicansComplement C3Complement Pathway, AlternativeComplement Pathway, ClassicalMannansAntibodies, MonoclonalComplement C3Immunoglobulin MMannansphosphomannan

Identifiers

PMID9826391
PMCPMC108767
OpenAlexW2168827662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.