ArticleInfection and immunity1998
Salmonella typhimurium infection in mice induces nitric oxide-mediated immunosuppression through a natural killer cell-dependent pathway.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Revisiting PersistentPathogens (Basel, Switzerland) · 2021Review
- Innate Activation of IFN-γ-iNOS Axis During Infection WithFrontiers in immunology · 2020Article
- Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.The Journal of experimental medicine · 2014Article
- Inflammation induced by phytomodulatory proteins from the latex of Calotropis procera (Asclepiadaceae) protects against Salmonella infection in a murine model of typhoid fever.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Transcriptional response in the peripheral blood of patients infected with Salmonella enterica serovar Typhi.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Tolerance in the absence of autoantigen.Endocrine, metabolic & immune disorders drug targets · 2007Review
- In vivo-selected mutations in methyl-directed mismatch repair suppress the virulence attenuation of Salmonella dam mutant strains following intraperitoneal, but not oral, infection of naïve mice.Journal of bacteriology · 2007Article
- Morphine withdrawal lowers host defense to enteric bacteria: spontaneous sepsis and increased sensitivity to oral Salmonella enterica serovar Typhimurium infection.Infection and immunity · 2006Article
- Salmonella inhibit T cell proliferation by a direct, contact-dependent immunosuppressive effect.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Increased sensitivity to Salmonella enterica serovar Typhimurium infection in mice undergoing withdrawal from morphine is associated with suppression of interleukin-12.Infection and immunity · 2005Article
- Review
- Host response to a dam mutant of Salmonella enterica serovar enteritidis with a temperature-sensitive phenotype.Infection and immunity · 2004Article
- Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The quantity of nitric oxide released by macrophages regulates Chlamydia-induced disease.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Nitric oxide and apoptosis induced in Peyer's patches by attenuated strains of Salmonella enterica serovar Enteritidis.Infection and immunity · 2002Article
- Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis.Infection and immunity · 2001Article
- Salmonella DNA adenine methylase mutants confer cross-protective immunity.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Splenocytes isolated from C57BL/6J female mice 3 to 7 days after inoculation with an attenuated strain of Salmonella typhimurium produced high levels of nitric oxide (39 to 77 microM) and gamma interferon (IFN-gamma). Additionally, spleen cell cultures from Salmonella-inoculated mice were markedly suppressed in their ability to generate an in vitro plaque-forming cell (PFC) response to sheep erythrocytes. Depletion of natural killer (NK) cells from the immune splenocyte population markedly reduced nitric oxide production, prevented suppression of PFC responses, and completely abrogated IFN-gamma release. Treatment of NK cell-depleted immune cells with IFN-gamma restored nitric oxide production to levels comparable to those of intact immune cells and also restored the immunosuppression. These results suggest that NK cells regulate the induction of nitric oxide-mediated immunosuppression following infection with S. typhimurium through the production of IFN-gamma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.