ArticleGut1998
Increased state of activation of CD4 positive T cells and elevated interferon gamma production in pouchitis.
Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 91 citations in OpenAlex.
- Endoscopic Application of GM-CSF, Fosfomycin, and Metronidazole in Pouchitis, a Phase I Safety and Pilot Study.Digestive diseases and sciences · 2026Article
- Cellular and molecular mechanisms in the pathogenesis of pouchitis: more than just the microbiota.Gut · 2025Review
- Effects of fecal stream deprivation on human intestinal barrier after loop ileostomy.Journal of gastroenterology and hepatology · 2022Article
- Isolation of lymphocytes from the human gastric mucosa.World journal of methodology · 2021Review
- Immune Microenvironment: New Insight for Familial Adenomatous Polyposis.Frontiers in oncology · 2021Review
- The relationship between preoperative T helper cytokines in the ileal mucosa and the pathogenesis of pouchitis.BMC gastroenterology · 2020Article
- Review article: the pathogenesis of pouchitis.Alimentary pharmacology & therapeutics · 2016Review
- Reduced neurons in the ileum of proctocolectomized rat models.Medical molecular morphology · 2015Article
- Acute and chronic pouchitis--pathogenesis, diagnosis and treatment.Nature reviews. Gastroenterology & hepatology · 2012Review
- The bacterial pathogenesis and treatment of pouchitis.Therapeutic advances in gastroenterology · 2010Article
- Activation of signal transducer and activator of transcription-1 (STAT-1) and differential expression of interferon-gamma and anti-inflammatory proteins in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis.Clinical and experimental immunology · 2010Article
- Diagnosis and treatment of pouchitis.Gastroenterology & hepatology · 2008Article
- Pouchitis.World journal of gastroenterology · 2007Review
- [Ileo pouch-anal anastomosis].Der Internist · 2007Review
- Increased cytokine transcripts in pouchitis reflect the degree of inflammation but not the underlying entity.International journal of colorectal disease · 2006Article
- Pouchitis: a spectrum of diseases.Current gastroenterology reports · 2005Review
- Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis.World journal of gastroenterology · 2005Article
- Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease.International journal of colorectal disease · 2004Article
- CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue.International journal of colorectal disease · 2004Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmunoregulatory abnormalities of T cells might be of importance in the pathogenesis of pouchitis after ileoanal pouch anastomosis (IAP).
aimsTo characterise T cell subsets, their state of activation, and production of cytokines in inflamed and non-inflamed pouches in patients with ulcerative colitis (UC) and familial adenomatous polyposis (FAP). The influence of T cell activation on mucosal transformation was also studied. PATIENTS: Mucosal biopsy specimens were taken from 42 patients with IAP (33 with UC and nine with FAP).
methodsMononuclear cells were isolated by standard techniques and characterised by three colour flow cytometry. Interferon gamma (IFN-gamma) production was studied using the ELISPOT technique.
resultsIn patients with UC with pouchitis there was a significant increase in the CD4:CD8 ratio, expression of activation markers on CD3+ cells, and number of IFNgamma producing mononuclear cells compared with patients with UC without pouchitis (CD4:CD8 ratio 1.3 (range 0.7-2.7) versus 0.6 (0. 1-1.0), p=0.012). In addition, a positive correlation between increased crypt depth and the number of CD4+ cells (r=0.57) was shown.
conclusionThe observed increase in activated mucosal CD4+ T cells and IFN-gamma production might lead to mucosal destruction and crypt hyperplasia as seen in pouchitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.