Trial reportGut1998
Effect of omeprazole 20 mg twice daily on duodenogastric and gastro-oesophageal bile reflux in Barrett's oesophagus.
Trial report in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Do proton pump inhibitors prevent Barrett's esophagus progression to high-grade dysplasia and esophageal adenocarcinoma? An updated meta-analysis.Journal of cancer research and clinical oncology · 2021Pooled it
- Rabeprazole combined with hydrotalcite is effective for patients with bile reflux gastritis after cholecystectomy.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2010Trial
- Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux.World journal of gastroenterology · 2005Trial
- Trial
- Long-term results of a randomized prospective study comparing medical and surgical treatment of Barrett's esophagus.Annals of surgery · 2003Trial
- Endoscopic Transoral Outlet Reduction for the Treatment of Biliary Reflux Symptoms in Patients After One-Anastomosis Gastric Bypass-a Case Series.Obesity surgery · 2023Article
- Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries.JAMA oncology · 2018Article
- Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.Oncotarget · 2017Article
- Control of acid and duodenogastroesophageal reflux (DGER) in patients with Barrett's esophagus.The American journal of gastroenterology · 2015Article
- In vitro effects of rabeprazole on human pylorus tone.Journal of neurogastroenterology and motility · 2015Article
- Rabeprazole is effective for bile reflux oesophagitis after total gastrectomy in a rat model.World journal of gastrointestinal pathophysiology · 2015Article
- Effect of proton pump inhibition on acid, weakly acid and weakly alkaline gastro-esophageal reflux in children.World journal of pediatrics : WJP · 2013Article
- Patients with refractory gastroesophageal reflux disease: diagnostic tools.Annals of gastroenterology · 2013Review
- Significant increase of esophageal mucin secretion in patients with reflux esophagitis after healing with rabeprazole: its esophagoprotective potential.Digestive diseases and sciences · 2009Article
- Yield of 24-hour esophageal pH and bilitec monitoring in patients with persisting symptoms on PPI therapy.Digestive diseases and sciences · 2008Article
- Review
- Ambulatory pH Monitoring: New Advances and Indications.Gastroenterology & hepatology · 2006Article
- Duodenogastric Reflux-induced (Alkaline) Esophagitis.Current treatment options in gastroenterology · 2004Article
- Barrett's esophagus without esophageal stricture does not increase the rate of failure of Nissen fundoplication.Annals of surgery · 2003Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth acid and duodenal contents are thought to be responsible for the mucosal damage in Barrett's oesophagus, a condition often treated medically. However, little is known about the effect of omeprazole on duodenogastric reflux (DGR) and duodenogastro-oesophageal reflux (DGOR).
aimsTo study the effect of omeprazole 20 mg twice daily on DGR and DGOR, using the technique of ambulatory bilirubin monitoring.
methodsTwenty three patients with Barrett's oesophagus underwent manometry followed by 24 hour oesophageal and gastric pH monitoring. In conjunction with pH monitoring, 11 patients (group 1) underwent oesophageal bilirubin monitoring and 12 patients (group 2) underwent gastric bilirubin monitoring, both before and during treatment with omeprazole 20 mg twice daily.
resultsIn both groups there was a significant reduction in oesophageal acid (pH<4) reflux (p<0.005) and a significant increase in the time gastric pH was above 4 (p<0.005). In group 1, median total oesophageal bilirubin exposure was significantly reduced from 28.9% to 2.4% (p<0.005). In group 2, median total gastric bilirubin exposure was significantly reduced from 24.9% to 7.2% (p<0.005).
conclusionsTreatment of Barrett's oesophagus with omeprazole 20 mg twice daily results in a notable reduction in the exposure of the oesophagus to both acid and duodenal contents. In addition, delivery of duodenal contents to the upper gastric body is reduced.
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