ArticleChest1998
Benefits of high-dose i.v. immunoglobulin in patients with severe steroid-dependent asthma.
Article in Chest, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 37 citations in OpenAlex.
- Current Issues in the Management of IgG Subclass Deficiencies in Adults With Chronic Respiratory Diseases.Allergy, asthma & immunology research · 2023Review
- Effects of Immunoglobulin Replacement on Asthma Exacerbation in Adult Asthmatics with IgG Subclass Deficiency.Allergy, asthma & immunology research · 2017Article
- Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases.Journal of Korean medical science · 2016Article
- The role of intravenous immunoglobulin in treatment of mucous membrane pemphigoid: A review of literature.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- The protective role of immunoglobulins in fungal infections and inflammation.Seminars in immunopathology · 2015Review
- The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcγ receptor IIb on CD11c(+) dendritic cells in a murine model.Clinical and experimental immunology · 2010Article
- Asthma that is unresponsive to usual care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010Review
- Basic and clinical immunology of Siglecs.Annals of the New York Academy of Sciences · 2008Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveTo determine the efficacy of IV immunoglobulin (IVIg) in severe asthma to reduce steroid requirements.
designPre- and posttreatment measurements were analyzed using Dunnett's multiple comparison procedure.
settingHospital clinical research center. PATIENTS: Eleven adolescents and adults with severe, steroid-dependent asthma enrolled over a 14-month period.
interventionsIVIg was administered at a dose of 2 g/kg every 4 weeks for a total of seven infusions. MEASUREMENTS AND
resultsSteroid requirements, pulmonary function including lung volumes, symptom scores, bone densitometry, and airway reactivity monitored by methacholine challenge were followed over the course of 7 months. A significant decrease in steroid usage was achieved. Despite substantial steroid reduction, the patients demonstrated improvement in their pulmonary function and symptom scores. The responses to methacholine challenge were unaffected by IVIg treatment.
conclusionsIVIg provides a potentially important adjunctive therapy in severe asthma, reducing oral steroid requirements and steroid side effects without deterioration of lung function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.