ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
The lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- The genome of the simultaneously hermaphroditic snail Lymnaea stagnalis reveals an evolutionary expansion of FMRFamide-like receptors.Scientific reports · 2024Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Immunohistochemical localisation of vasopressin/oxytocin-type, corazonin-type and luqin-type neuropeptide expression in the starfish Asterias rubens using antibodies to the C-terminal region of precursor proteins.Cell and tissue research · 2023Article
- Transcriptome Profiling of the Pacific OysterMarine drugs · 2021Article
- Neuropeptide Localization inFrontiers in molecular neuroscience · 2021Review
- Evolution and Comparative Physiology of Luqin-Type Neuropeptide Signaling.Frontiers in neuroscience · 2020Review
- Emergence of a cholecystokinin/sulfakinin signalling system in Lophotrochozoa.Scientific reports · 2018Article
- Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome.Scientific reports · 2018Article
- Identification and Characterization of Neuropeptides by Transcriptome and Proteome Analyses in a Bivalve MolluscFrontiers in genetics · 2018Article
- Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution.Open biology · 2016Article
- Diversity of the RFamide Peptide Family in Mollusks.Frontiers in endocrinology · 2014Review
- A review of FMRFamide- and RFamide-like peptides in metazoa.Invertebrate neuroscience : IN · 2009Article
- Neuropeptides.WormBook : the online review of C. elegans biology · 2008Review
- Endocrine disruption in aquatic pulmonate molluscs: few evidences, many challenges.Ecotoxicology (London, England) · 2007Review
- Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Molecular cloning and functional expression of the first insect FMRFamide receptor.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Conformational ensembles: the role of neuropeptide structures in receptor binding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel G-protein-coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the mollusc Lymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium-dependent chloride channel. Using this response as a bioassay, we purified the ligand for GRL106, Lymnaea cardioexcitatory peptide (LyCEP), an RFamide-type decapeptide (TPHWRPQGRF-NH2) displaying significant similarity to the Achatina cardioexcitatory peptide (ACEP-1) as well as to the recently identified family of mammalian prolactin-releasing peptides. In the Lymnaea brain, the cells that produce egg-laying hormone are the predominant site of GRL106 gene expression and appear to be innervated by LyCEP-containing fibers. Indeed, LyCEP application transiently hyperpolarizes isolated egg-laying hormone cells. In the Lymnaea pericardium, LyCEP-containing fibers end blindly at the pericardial lumen, and the heart is stimulated by LyCEP in vitro. These data confirm that LyCEP is an RFamide ligand for GRL106.
Indexed as
Identifiers
9822740PMC6793288W2128699465What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.