ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Neuronal receptors mediating responses to antibodyactivated laminin-1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
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- Article
- Integrins promote axonal regeneration after injury of the nervous system.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections.Neural development · 2013Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis.Developmental cell · 2010Article
- Physiological and pathological roles of alpha3beta1 integrin.The Journal of membrane biology · 2004Review
- A novel cAMP-dependent pathway activates neuronal integrin function in retinal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The critical role of basement membrane-independent laminin gamma 1 chain during axon regeneration in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The permissive cue laminin is essential for growth cone turning in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Regulation of neurite outgrowth by integrin activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Impaired axonal regeneration in alpha7 integrin-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Embryonic retinal neurons lose the ability to extend neurites on laminin-1 (LN-1) with increasing developmental age yet still do so on other laminin isoforms. However, after treatment of LN-1 with antibodies to "short-arm" regions or removal of the short arms proteolytically, LN-1 supports attachment and extension of neurites even by late embryonic retinal neurons. We have mapped a domain for antibody-mediated "activation" of LN-1 to the N-terminal end of the alpha1 chain. Furthermore, we show that the primary receptors used in the retinal neuron response to "activated" LN-1 are integrins alpha3 beta1 and alpha6 beta1; these are the same receptors used by these neurons for outgrowth on other LN isoforms. Interestingly, alpha3 beta1 is preferentially involved in neurite outgrowth, whereas alpha6beta1 preferentially mediates attachment and spreading. However, in cultures from alpha3 integrin-deficient mice, alpha6 beta1 mediates retinal ganglion cell neurite outgrowth and compensates for the absence of alpha3 beta1. Finally, we show that key features of the retinal neuron response to LN-1 also characterize neurons of the hippocampus, thalamus, and cerebral cortex; these include poor response to untreated LN-1, extensive neurite outgrowth on antibody-activated LN-1 or on fragment E8, and dependence of this response on integrin alpha6 beta1 and at least one other long arm-binding beta1 integrin. These data suggest that regulation of LN-1 function via the process of activation could have important consequences for axonal regeneration. Curiously, the data also imply that the mechanism of laminin activation involves enhanced function at sites that cannot be considered cryptic.
Indexed as
Identifiers
9822731PMC6793292W2156735951What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.