ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus.Journal of neuroinflammation · 2023Article
- Extracellular matrix and synapse formation.Bioscience reports · 2023Article
- Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.Journal of extracellular vesicles · 2020Article
- The role of agrin in synaptic development, plasticity and signaling in the central nervous system.Neurochemistry international · 2012Review
- Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?The journal of headache and pain · 2011Article
- Emerging roles for MAP kinases in agrin signaling.Communicative & integrative biology · 2011Article
- Agrin downregulation induced by nerve injury contributes to neuropathic pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Cell adhesion to agrin presented as a nanopatterned substrate is consistent with an interaction with the extracellular matrix and not transmembrane adhesion molecules.BMC cell biology · 2008Article
- Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Contribution of downregulation of L-type calcium currents to delayed neuronal death in rat hippocampus after global cerebral ischemia and reperfusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.Journal of cell science · 2005Article
- Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons.The Journal of cell biology · 2003Article
- Agrin plays an organizing role in the formation of sympathetic synapses.The Journal of cell biology · 2002Article
- Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Agrin controls synaptic differentiation in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Agrin isoforms with distinct amino termini: differential expression, localization, and function.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The synaptic basal lamina protein agrin is essential for the formation of neuromuscular junctions. Agrin mediates the postsynaptic clustering of acetylcholine receptors and regulates transcription in muscles. Agrin expression is not restricted to motor neurons but can be demonstrated throughout the CNS. The functional significance of agrin expression in neurons other than motor neurons is unknown. To test whether agrin triggers responses in neurons that lead to the activation of transcription factors, we have analyzed phosphorylation of the transcriptional regulatory site serine 133 of the transcription factor CREB (cAMP response element binding protein) in primary hippocampal neurons. Our results indicate that the neuronal (Ag4,8), but not the non-neuronal (Ag0,0), isoform of agrin induces CREB phosphorylation in hippocampal neurons. The kinetics of agrin- and BDNF-induced CREB phosphorylation are similar: peak levels are reached in minutes and are strongly reduced 2 hr later. Neuronal responses to agrin require extracellular calcium, and, in contrast to tyrosine kinase inhibitors, the specific inhibition of protein kinase A (PKA) does not affect agrin-evoked CREB phosphorylation. Our results show that hippocampal neurons specifically respond to neuronal agrin in a Ca2+-dependent manner and via the activation of tyrosine kinases.
Indexed as
Identifiers
9822730PMC6793297W1770029100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.