ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
A product of the Drosophila stoned locus regulates neurotransmitter release.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Modeling AP2M1 developmental and epileptic encephalopathy in Drosophila.Disease models & mechanisms · 2025Article
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- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- AP180 couples protein retrieval to clathrin-mediated endocytosis of synaptic vesicles.Traffic (Copenhagen, Denmark) · 2014Article
- Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Ca2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1.PloS one · 2012Article
- Stoned B mediates sorting of integral synaptic vesicle proteins.Neuroscience · 2008Article
- Molecular and genetic characterization of the interactions between the Drosophila stoned-B protein and DAP-160 (intersectin).The Biochemical journal · 2005Article
- Isoflurane depresses glutamate release by reducing neuronal excitability at the Drosophila neuromuscular junction.The Journal of physiology · 2004Article
- Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Article
- Role of synaptotagmin in Ca2+-triggered exocytosis.The Biochemical journal · 2002Review
- Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila.Genes & development · 2001Article
- Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating.EMBO reports · 2001Article
- Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.The Journal of cell biology · 2001Article
- Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Interaction of stoned and synaptotagmin in synaptic vesicle endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The Drosophila stoned locus encodes two novel gene products termed stonedA and stonedB, which possess sequence motifs shared by proteins involved in intracellular vesicle traffic. A specific requirement for stoned in the synaptic vesicle cycle has been suggested by synthetic genetic interactions between stoned and shibire, a gene essential for synaptic vesicle recycling (Petrovich et al., 1993). A synaptic role of stoned gene products also is suggested by altered synaptic transients in electroretinograms recorded from stoned mutant eyes (Petrovich et al., 1993). We show here that the stonedA protein is highly enriched at Drosophila nerve terminals. Mutant alleles that affect stonedA disrupt the normal regulation of synaptic vesicle exocytosis at neuromuscular synapses of Drosophila. Spontaneous neurotransmitter release is enhanced dramatically, and evoked release is reduced substantially in such stoned mutants. Ultrastructural studies reveal no evidence of major disorganization at stoned mutant nerve terminals. Thus, our data indicate a direct role for stonedA in regulating synaptic vesicle exocytosis. However, genetic and morphological observations suggest additional, subtle effects of stoned mutations on synaptic vesicle recycling. Remarkably, almost all phenotypes of stoned mutants are similar to those previously described for mutants of synaptotagmin, a protein postulated to regulate both exocytosis and the recycling of synaptic vesicles. We propose a model in which stonedA functions together with synaptotagmin to regulate synaptic vesicle cycling.
Indexed as
Identifiers
9822725PMC6793315W1884868796What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.