ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Requirement for the NINAC kinase/myosin for stable termination of the visual cascade.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Transcriptomic Characterization of Phototransduction Genes of the Asian Citrus PsyllidInsects · 2024Article
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors.Journal of neurophysiology · 2013Article
- PDA (prolonged depolarizing afterpotential)-defective mutants: the story of nina's and ina's--pinta and santa maria, too.Journal of neurogenetics · 2012Review
- Mouse class III myosins: kinase activity and phosphorylation sites.Journal of neurochemistry · 2011Article
- Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.Experimental eye research · 2009Article
- Primary processes in sensory cells: current advances.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Review
- Drosophila photoreceptors and signaling mechanisms.Frontiers in cellular neuroscience · 2009Article
- Article
- Role of protein phosphatase 2A in regulating the visual signaling in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Phototransduction and retinal degeneration in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylation.Biochemistry · 2007Article
- Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus.Molecular biology of the cell · 2003Article
- From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Does Ca2+ reach millimolar concentrations after single photon absorption in Drosophila photoreceptor microvilli?Biophysical journal · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Activation of the Drosophila photoresponse is a rapid process that results in plasma membrane Ca2+ and Na+ conductances. Ca2+ functions in negative feedback regulation of Drosophila vision including deactivation. Protein kinase C (PKC) binds directly to Ca2+ and is required for deactivation. However, the consequences of disrupting phosphorylation of any individual PKC substrate in the Drosophila retina have not been addressed. In the current work, we show that NINAC p174, which consists of a protein kinase domain joined to the head region of myosin heavy chain, is a phosphoprotein and is phosphorylated in vitro by PKC. Mutation of either of two PKC sites in the p174 tail resulted in an unusual defect in deactivation that had not been detected previously for other ninaC alleles or other loci. After cessation of the light stimulus, there appeared to be a transient reactivation of the visual cascade. This phenotype suggests that a mechanism exists to prevent reactivation of the visual cascade and that p174 participates in this process.
Indexed as
Identifiers
9822721PMC6793282W1932075839What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.