ArticleThe EMBO journal1998
Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 142 citations in OpenAlex.
- Crucial roles of mesenchymalProceedings of the National Academy of Sciences of the United States of America · 2025Article
- GATA2 Mediates Macrophage Proliferation During Atherosclerosis.Journal of the American Heart Association · 2025Article
- A Hierarchy of Luminal Transcription Factors Defines AR Cistrome and Is Lost in Neuroendocrine Prostate Cancer.Cancer heterogeneity and plasticity · 2025Article
- Cellular specificity of androgen receptor, coregulators, and pioneer factors in prostate cancer.Endocrine oncology (Bristol, England) · 2022Review
- GATA2 deficiency syndrome: A decade of discovery.Human mutation · 2021Article
- Vascular endothelial cell specification in health and disease.Angiogenesis · 2021Review
- Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems.Biomedicines · 2021Review
- A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types.Stem cell reports · 2020Article
- Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors.Cancer research · 2020Review
- GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis throughDevelopment (Cambridge, England) · 2019Article
- Developmental pathology of congenital kidney and urinary tract anomalies.Clinical kidney journal · 2019Article
- GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice.Cancer science · 2019Article
- Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury.Molecular and cellular biology · 2017Article
- GATA2 expression and biochemical recurrence following salvage radiation therapy for relapsing prostate cancer.The British journal of radiology · 2017Article
- The role of GATA2 in lethal prostate cancer aggressiveness.Nature reviews. Urology · 2017Review
- Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defect.Molecular and cellular biology · 2016Article
- Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor.Molecular biology and evolution · 2016Article
- GATA2 is required for lymphatic vessel valve development and maintenance.The Journal of clinical investigation · 2015Article
- Haematopoietic and immune defects associated with GATA2 mutation.British journal of haematology · 2015Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Mutations resulting in embryonic or early postnatal lethality could mask the activities of any gene in unrelated and temporally distinct developmental pathways. Targeted inactivation of the transcription factor GATA-2 gene leads to mid-gestational death as a consequence of hematopoietic failure. We show here that a 250 kbp GATA-2 yeast artificial chromosome (YAC) is expressed strongly in both the primitive and definitive hematopoietic compartments, while two smaller YACs are not. This largest YAC also rescues hematopoiesis in vitro and in vivo, thereby localizing the hematopoietic regulatory cis element(s) to between 100 and 150 kbp 5' to the GATA-2 structural gene. Introducing the YAC transgene into the GATA-2(-/-) genetic background allows the embryos to complete gestation; however, newborn rescued pups quickly succumb to lethal hydroureternephrosis, and display a complex array of genitourinary abnormalities. These findings reveal that GATA-2 plays equally vital roles in urogenital and hematopoietic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.