ReviewThe EMBO journal1998
Replication errors: cha(lle)nging the genome.
Review in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 205 citations in OpenAlex.
- Associations Between Non-Genetic Risk Factors and DNA Methylation Alterations in Barrett's Esophagus and Its Progression to Esophageal Adenocarcinoma.International journal of molecular sciences · 2025Review
- Evidence of response to pembrolizumab in a patient with Lynch syndrome-related metastatic colon cancer.OncoTargets and therapy · 2018Article
- Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia.Oncology letters · 2017Article
- Life without dUTPase.Frontiers in microbiology · 2016Article
- DNA triplet repeat expansion and mismatch repair.Annual review of biochemistry · 2015Review
- Mismatch repair protein expression in colorectal cancer.Journal of gastrointestinal oncology · 2013Article
- Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.Nature genetics · 2013Article
- Postreplicative mismatch repair.Cold Spring Harbor perspectives in biology · 2013Review
- Article
- DNA damage and repair in epithelium after allogeneic hematopoietic stem cell transplantation.International journal of molecular sciences · 2012Review
- Involvement of mismatch repair in the reciprocal control of motility and adherence of uropathogenic Escherichia coli.Infection and immunity · 2012Article
- Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D).The Journal of biological chemistry · 2012Article
- Helicobacter pylori infection and expression of DNA mismatch repair proteins.World journal of gastroenterology · 2008Article
- Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts.Oncogene · 2008Article
- The RAD5-dependent postreplication repair pathway is important to suppress gross chromosomal rearrangements.Journal of the National Cancer Institute. Monographs · 2008Article
- Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications.Molecular cancer · 2007Review
- Clinical and molecular analysis of hereditary non-polyposis colorectal cancer in Chinese colorectal cancer patients.World journal of gastroenterology · 2007Article
- Involvement of mismatch repair in transcription-coupled nucleotide excision repair.Human cell · 2005Review
- Recognition and binding of mismatch repair proteins at an oncogenic hot spot.BMC molecular biology · 2005Article
- Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.Biochemistry · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the discovery of a link between the malfunction of post-replicative mismatch correction and hereditary non-polyposis colon cancer, the study of this complex repair pathway has received a great deal of attention. Our understanding of the mammalian system was facilitated by conservation of the main protagonists of this process from microbes to humans. Thus, biochemical experiments carried out with Escherichia coli extracts helped us to identify functional human homologues of the bacterial mismatch repair proteins, while the genetics of Saccharomyces cerevisiae aided our understanding of the phenotypes of human cells deficient in mismatch correction. Today, mismatch repair is no longer thought of solely as the mechanism responsible for the correction of replication errors, whose failure demonstrates itself in the form of a mutator phenotype and microsatellite instability. Malfunction of this process has been implicated also in mitotic and meiotic recombination, drug and ionizing radiation resistance, transcription-coupled repair and apoptosis. Elucidation of the roles of mismatch repair proteins in these transduction pathways is key to our understanding of the role of mismatch correction in human cancer. However, in order to unravel all the complexities involved in post-replicative mismatch correction, we need to know the cast and the roles of the individual players. This brief treatise provides an overview of our current knowledge of the biochemistry of this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.