Evidence map›Paper›PMID 9820800›Full record

ReviewThe Biochemical journal1998

Molecular aspects of the endocytic pathway.

M J Clague

Abstract readReview
In one paragraph

Review in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
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  5. Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic CaJournal of molecular and cellular cardiology · 2019
    Article
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  7. Review
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  12. Article
  13. Review
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

M J ClaguePhysiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, U.K. clague@liv.ac.uk

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Observation of the flow of material along the endocytic pathway has lead to the description of the basic architecture of the pathway and provided insight into the relationship between compartments. Significant advances have been made in the study of endocytic transport steps at the molecular level, of which studies of cargo selection, vesicle budding and membrane fusion events comprise the major part. Progress in this area has been driven by two approaches, yeast genetics and in vitro or cell-free assays, which reconstitute particular transport steps and allow biochemical manipulation. The complex protein machineries that control vesicle budding and fusion are significantly conserved between the secretory and endocytic pathways such that proteins that regulate particular steps are often part of a larger family of proteins which exercise a conserved function at other locations within the cell. Well characterized examples include vesicle coat proteins, rabs (small GTPases) and soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein (SNAP) receptors (SNAREs). Intracompartmental pH, lipid composition and cytoskeletal organization have also been identified as important determinants of the orderly flow of material within the endocytic pathway.

Indexed as

rab GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsAdenosine TriphosphatasesAnimalsBiological TransportCell FusionCytoskeletonEndocytosisEndosomesGTP-Binding ProteinsGTP PhosphohydrolasesHumansLipid MetabolismPhosphatidylinositol 3-KinasesProteinsVacuolesAdenosine TriphosphatasesGTP-Binding ProteinsGTP PhosphohydrolasesPhosphatidylinositol 3-KinasesProteinsrab GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsYPT1 protein, S cerevisiae

Identifiers

PMID9820800
PMCPMC1219867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.