ArticleMolecular and cellular biology1998
Highly conserved RNA sequences that are sensors of environmental stress.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
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- Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.PloS one · 2021Article
- Nucleotide diversity analysis highlights functionally important genomic regions.Scientific reports · 2016Article
- Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum.Nucleic acids research · 2015Article
- Long conserved fragments upstream of Mammalian polyadenylation sites.Genome biology and evolution · 2011Article
- Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.Molecular cell · 2008Article
- Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis.Nucleic acids research · 2007Article
- Article
- Heat shock protein 70 binds its own messenger ribonucleic acid as part of a gene expression self-limiting mechanism.Cell stress & chaperones · 2006Article
- The 3' region of human papillomavirus type 16 early mRNAs decrease expression.BMC infectious diseases · 2005Article
- The mammalian transcriptome and the function of non-coding DNA sequences.Genome biology · 2004Review
- Comparative analysis of orthologous eukaryotic mRNAs: potential hidden functional signals.Nucleic acids research · 2004Article
- Patterns in interspecies similarity correlate with nucleotide composition in mammalian 3'UTRs.Nucleic acids research · 2003Article
- Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci.Genome research · 2002Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The putative function of highly conserved regions (HCRs) within 3' untranslated regions (3'UTRs) as regulatory RNA sequences was efficiently and quantitatively assessed by using modular retroviral vectors. This strategy led to the identification of HCRs that alter gene expression in response to oxidative or mitogenic stress. Databases were screened for UTR sequences of >100 nucleotides that had retained 70% identity over more than 300 million years of evolution. The effects of 10 such HCRs on a standard reporter mRNA or protein were studied. To this end, we developed a modular retroviral vector that can allow for a direct comparison of the effects of different HCRs on gene expression independent of their gene-intrinsic 5'UTR, promoter, protein coding region, or poly(A) sequence. Five of the HCRs tested decreased mRNA steady-state levels 2- to 10-fold relative to controls, presumably by altering mRNA stability. One HCR increased translation, and one decreased translation. Elevated mitogen levels caused four HCRs to increase protein levels twofold. One HCR increased protein levels fourfold in response to hypoxia. Although nonconserved UTR sequences may also have a role, these results provide evidence that sequences that are highly conserved during evolution are good candidates for RNA motifs with posttranscriptional regulatory functions in gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.