ArticleMolecular and cellular biology1998
Multiple orientation-dependent, synergistically interacting, similar domains in the ribosomal DNA replication origin of the fission yeast, Schizosaccharomyces pombe.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeastThe Journal of biological chemistry · 2017Article
- Identification of two telomere-proximal fission yeast DNA replication origins constrained by nearby cis-acting sequences to replicate in late S phase.F1000Research · 2012Article
- Integrity of chromatin and replicating DNA in nuclei released from fission yeast by semi-automated grinding in liquid nitrogen.BMC research notes · 2011Article
- Defining the replication program through the chromatin landscape.Critical reviews in biochemistry and molecular biology · 2011Review
- Differential targeting of Tetrahymena ORC to ribosomal DNA and non-rDNA replication origins.The EMBO journal · 2009Article
- Checkpoint independence of most DNA replication origins in fission yeast.BMC molecular biology · 2007Article
- Tetrahymena ORC contains a ribosomal RNA fragment that participates in rDNA origin recognition.The EMBO journal · 2007Article
- Role of the Orc6 protein in origin recognition complex-dependent DNA binding and replication in Drosophila melanogaster.Molecular and cellular biology · 2007Article
- DNA elements modulating the KARS12 chromosomal replicator in Kluyveromyces lactis.Molecular genetics and genomics : MGG · 2007Article
- Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.Nucleic acids research · 2007Article
- DNA replication origins in the Schizosaccharomyces pombe genome.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Defined sequence modules and an architectural element cooperate to promote initiation at an ectopic mammalian chromosomal replication origin.Molecular and cellular biology · 2004Article
- The human beta-globin replication initiation region consists of two modular independent replicators.Molecular and cellular biology · 2004Article
- Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR.Nucleic acids research · 2003Article
- Sequence-independent DNA binding and replication initiation by the human origin recognition complex.Genes & development · 2003Article
- Xenopus origin recognition complex (ORC) initiates DNA replication preferentially at sequences targeted by Schizosaccharomyces pombe ORC.The EMBO journal · 2003Article
- Differential use of multiple replication origins in the ribosomal DNA episome of the protozoan parasite Entamoeba histolytica.Nucleic acids research · 2003Article
- Multiple functional elements comprise a Mammalian chromosomal replicator.Molecular and cellular biology · 2003Article
- Multiple ORC-binding sites are required for efficient MCM loading and origin firing in fission yeast.The EMBO journal · 2003Article
- Is DNA sequence sufficient to specify DNA replication origins in metazoan cells?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous investigations have shown that the fission yeast, Schizosaccharomyces pombe, has DNA replication origins (500 to 1500 bp) that are larger than those in the budding yeast, Saccharomyces cerevisiae (100 to 150 bp). Deletion and linker substitution analyses of two fission yeast origins revealed that they contain multiple important regions with AT-rich asymmetric (abundant A residues in one strand and T residues in the complementary strand) sequence motifs. In this work we present the characterization of a third fission yeast replication origin, ars3001, which is relatively small ( approximately 570 bp) and responsible for replication of ribosomal DNA. Like previously studied fission yeast origins, ars3001 contains multiple important regions. The three most important of these regions resemble each other in several ways: each region is essential for origin function and is at least partially orientation dependent, each region contains similar clusters of A+T-rich asymmetric sequences, and the regions can partially substitute for each other. These observations suggest that ars3001 function requires synergistic interactions between domains binding similar proteins. It is likely that this requirement extends to other fission yeast origins, explaining why such origins are larger than those of budding yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.