ArticleMolecular and cellular biology1998
C/EBPalpha is critical for the neonatal acute-phase response to inflammation.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 67 citations in OpenAlex.
- Transcription networks in liver development and acute liver failure.Liver research (Beijing, China) · 2023Review
- Neuronal ablation of mt-AspRS in mice induces immune pathway activation prior to severe and progressive cortical and behavioral disruption.Experimental neurology · 2020Article
- Hepatocytes: a key cell type for innate immunity.Cellular & molecular immunology · 2016Review
- Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice.Oncotarget · 2016Article
- Characterization of rat serum amyloid A4 (SAA4): a novel member of the SAA superfamily.Biochemical and biophysical research communications · 2014Article
- Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish.BMC pharmacology & toxicology · 2014Article
- LPS-induced inflammation in the chicken is associated with CCAAT/enhancer binding protein beta-mediated fat mass and obesity associated gene down-regulation in the liver but not hypothalamus.BMC veterinary research · 2013Article
- CCAAT/enhancer-binding protein δ is a critical mediator of lipopolysaccharide-induced acute lung injury.The American journal of pathology · 2013Article
- Mesenchymal-specific deletion of C/EBPβ suppresses pulmonary fibrosis.The American journal of pathology · 2012Article
- Gene expression profiling of liver from dairy cows treated intra-mammary with lipopolysaccharide.BMC genomics · 2008Article
- Innate immunity of the newborn: basic mechanisms and clinical correlates.Nature reviews. Immunology · 2007Review
- Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.The Journal of biological chemistry · 2003Article
- Platelet-activating factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine.British journal of pharmacology · 2001Article
- C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.Molecular and cellular biology · 2000Article
- Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer.The EMBO journal · 1999Article
- Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver.Archives of gerontology and geriatricsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Members of the C/EBP (CCAAT/enhancer binding protein) family of transcription factors play important roles in mediating the acute-phase response (APR), an inflammatory process resulting from infection and/or tissue damage. Among the C/EBP family of proteins, C/EBPbeta and -delta were thought to be the primary mediators of the APR. The function of C/EBPalpha in the APR has not been fully characterized to date. Here, we investigate the role of C/EBPalpha in the APR by using neonatal mice that lack C/EBPalpha expression. Northern blot analysis of acute-phase protein gene expression in neonatal mice treated with purified bacterial lipopolysaccharide or recombinant interleukin 1beta as an inflammation stimulus showed a strong APR in wild-type mice, but a response in C/EBPalpha null animals was completely lacking. The C/EBPalpha knockout and wild-type mice demonstrated elevations in C/EBPbeta and -delta mRNA expression and DNA binding as well as increased DNA binding of NF-kappaB, all of which are known to be important in the APR. Null mice, however, failed to activate STAT3 binding in response to lipopolysaccharide. Our results provide the first evidence that C/EBPalpha is absolutely required for the APR in neonatal mice, is involved in STAT3 regulation, and cannot be compensated for by other C/EBP family members.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.