ArticleMolecular and cellular biology1998
Role for a YY1-binding element in replication-dependent mouse histone gene expression.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Aurora A Phosphorylation of YY1 during Mitosis Inactivates its DNA Binding Activity.Scientific reports · 2017Article
- The HIST1 Locus Escapes Reprogramming in Cloned Bovine Embryos.G3 (Bethesda, Md.) · 2016Article
- Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes.Development (Cambridge, England) · 2016Article
- Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins.Oncotarget · 2015Article
- A conserved interaction that is essential for the biogenesis of histone locus bodies.The Journal of biological chemistry · 2014Article
- Yin Yang 1 intronic binding sequences and splicing elicit intron-mediated enhancement of ubiquitin C gene expression.PloS one · 2013Article
- YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas.Nucleic acids research · 2012Article
- Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.Molecular and cellular biology · 2012Article
- Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells.Cell cycle (Georgetown, Tex.) · 2012Article
- The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle.PloS one · 2012Article
- The transcription factor YY1 is a substrate for Polo-like kinase 1 at the G2/M transition of the cell cycle.PloS one · 2011Article
- The oncogenic role of Yin Yang 1.Critical reviews in oncogenesis · 2011Review
- Regulation of the transcription factor YY1 in mitosis through phosphorylation of its DNA-binding domain.Molecular biology of the cell · 2009Article
- Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element.Nucleic acids research · 2009Article
- Article
- Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.Molecular and cellular biology · 2008Article
- Tissue-specific chromatin modifications at a multigene locus generate asymmetric transcriptional interactions.Molecular and cellular biology · 2006Article
- Multiple independent evolutionary solutions to core histone gene regulation.Genome biology · 2006Article
- Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs.Genes & development · 2005Article
- Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the highly conserved replication-dependent histone gene family increases dramatically as a cell enters the S phase of the eukaryotic cell cycle. Requirements for normal histone gene expression in vivo include an element, designated alpha, located within the protein-encoding sequence of nucleosomal histone genes. Mutation of 5 of 7 nucleotides of the mouse H3.2 alpha element to yield the sequence found in an H3.3 replication-independent variant abolishes the DNA-protein interaction in vitro and reduces expression fourfold in vivo. A yeast one-hybrid screen of a HeLa cell cDNA library identified the protein responsible for recognition of the histone H3.2 alpha sequence as the transcription factor Yin Yang 1 (YY1). YY1 is a ubiquitous and highly conserved transcription factor reported to be involved in both activation and repression of gene expression. Here we report that the in vitro histone alpha DNA-protein interaction depends on YY1 and that mutation of the nucleotides required for the in vitro histone alpha DNA-YY1 interaction alters the cell cycle phase-specific up-regulation of the mouse H3.2 gene in vivo. Because all mutations or deletions of the histone alpha sequence both abolish interactions in vitro and cause an in vivo decrease in histone gene expression, the recognition of the histone alpha element by YY1 is implicated in the correct temporal regulation of replication-dependent histone gene expression in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.