ArticleMolecular and cellular biology1998
The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development.The Journal of clinical investigation · 2016Article
- Enzymatic intracrine regulation of white adipose tissue.Hormone molecular biology and clinical investigation · 2014Review
- The DN2 Myeloid-T (DN2mt) Progenitor is a Target Cell for Leukemic Transformation by the TLX1 Oncogene.Journal of bone marrow research · 2013Article
- NKL homeobox genes in leukemia.Leukemia · 2012Review
- The role of human aldehyde dehydrogenase in normal and cancer stem cells.Stem cell reviews and reports · 2011Review
- Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma.PloS one · 2011Article
- Lentiviral fluorescent protein expression vectors for biotinylation proteomics.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues.Journal of cellular and molecular medicine · 2010Review
- Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.Molecular cancer · 2010Article
- TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Molecular cancer · 2010Article
- Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Genes, chromosomes & cancer · 2010Article
- Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.Biochemical and biophysical research communications · 2009Article
- ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells.Molecular cancer · 2008Article
- Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- TLX1/HOX11-induced hematopoietic differentiation blockade.Oncogene · 2007Article
- The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells.Leukemia · 2006Article
- G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia.Oncogene · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox11 is a homeobox gene essential for spleen formation in mice, since atrophy of the anlage of a developing spleen occurs in early embryonic development in Hox11 null mice. HOX11 is also expressed in a subset of T-cell acute leukemias after specific chromosomal translocations. Since the protein has a homeodomain and can activate transcription, it probably exerts at least some of its effects in vivo by regulation of target genes. Representational difference analysis has been used to isolate cDNA clones corresponding to mRNA species activated following stable expression of HOX11 in NIH 3T3 cells. The gene encoding the retinoic acid-synthesizing enzyme aldehyde dehydrogenase 1 (Aldh1), initially called Hdg-1, was found to be ectopically activated by HOX11 in this system. Study of Aldh1 gene expression during spleen development showed that the presence of Aldh1 mRNA inversely correlated with Hox11. Hox11 null mouse embryos have elevated Aldh1 mRNA in spleen primordia prior to atrophy, while Aldh1 seems to be repressed by Hox11 during organogenesis of the spleens of wild-type mice. This result suggests that expression of Aldh1 protein is negatively regulated by Hox11 and that abnormal expression of Aldh1 in Hox11 null mice may cause loss of splenic precursor cells by aberrant retinoic acid metabolism.
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