ArticleThe Journal of clinical investigation1998
Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.
- Histamine receptors and COVID-19.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Pooled it
- Mast cell metabolism in cancer: an underexplored frontier demanding more attention.Frontiers in immunology · 2025Review
- Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets.Biomolecules · 2021Review
- What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk.Metabolites · 2021Review
- H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?Clinical and molecular allergy : CMA · 2021Article
- Acute Intestinal Inflammation Depletes/Recruits Histamine-Expressing Myeloid Cells From the Bone Marrow Leading to Exhaustion of MB-HSCs.Cellular and molecular gastroenterology and hepatology · 2021Article
- Behind Enemy Lines: Immunomodulatory Armamentarium of the Schistosome Parasite.Frontiers in immunology · 2020Review
- Type 2 Inflammatory Responses in Autoimmune Demyelination of the Central Nervous System: Recent Advances.Journal of immunology research · 2019Review
- Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice.Oncoimmunology · 2016Article
- Expression and function of histamine and its receptors in atopic dermatitis.Molecular and cellular pediatrics · 2015Article
- Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas.Oncoimmunology · 2015Article
- Article
- Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells.Journal of leukocyte biology · 2014Article
- Phosphodiesterase 4 inhibition in the treatment of psoriasis, psoriatic arthritis and other chronic inflammatory diseases.Dermatology and therapy · 2013Article
- Pharmacological therapy of gastroesophageal reflux in preterm infants.Gastroenterology research and practice · 2013Article
- Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis.BMC medicine · 2012Review
- Sphingolipids: a potential molecular approach to treat allergic inflammation.Journal of allergy · 2012Article
- Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells.Nature medicine · 2011Article
- Histamine inhibits adhesion molecule expression in human monocytes, induced by advanced glycation end products, during the mixed lymphocyte reaction.British journal of pharmacology · 2010Article
- Histamine plays an essential regulatory role in lung inflammation and protective immunity in the acute phase of Mycobacterium tuberculosis infection.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IL-12 is essential for T helper 1 (Th1) development and inhibits the induction of Th2 responses. Atopic diseases, which are characterized by Th2 responses, are associated with the overproduction of histamine. Here we present evidence that histamine, at physiological concentrations, strongly inhibits human IL-12 p40 and p70 mRNA and protein production by human monocytes. The use of specific histamine receptor antagonists reveals that this inhibition is mediated via the H2 receptor and induction of intracellular cAMP. The inhibition of IL-12 production is independent of IL-10 and IFN-gamma. The observation that histamine strongly reduces the production of the Th1-inducing cytokine IL-12 implies a positive feedback mechanism for the development of Th2 responses in atopic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.