ArticleThe Journal of allergy and clinical immunology1998
Influenza A virus infection increases IgE production and airway responsiveness in aerosolized antigen-exposed mice.
Article in The Journal of allergy and clinical immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Exacerbations and Management of Asthma in Viral Lower Respiratory Tract Infections: The Significance of Immunoglobulin E.Immunity, inflammation and disease · 2026Review
- Review
- Immunologic, genetic, and ecological interplay of factors involved in allergic diseases.Frontiers in allergy · 2023Review
- Plastic bronchitis associated with influenza B virus infection: A case report.Fukushima journal of medical science · 2022Article
- Previous Influenza Infection Exacerbates Allergen Specific Response and Impairs Airway Barrier Integrity in Pre-Sensitized Mice.International journal of molecular sciences · 2021Article
- Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice.Scientific reports · 2019Article
- Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations.Korean journal of pediatrics · 2014Article
- Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection.PloS one · 2014Article
- Immune evasion, immunopathology and the regulation of the immune system.Pathogens (Basel, Switzerland) · 2013Review
- Increased Prevalence of H1N1-Induced Severe Lower Respiratory Tract Diseases in Children With Atopic Sensitization.Allergy, asthma & immunology research · 2012Article
- Atopic Sensitization is Associated With Severe Lower Respiratory Illness in Children With Pandemic H1N1 Influenza Viral Infection.Allergy, asthma & immunology research · 2012Article
- Dendritic cells, viruses, and the development of atopic disease.Journal of allergy · 2012Article
- Sexual dimorphism in lung function responses to acute influenza A infection.Influenza and other respiratory viruses · 2011Article
- Unravelling synergistic immune interactions between respiratory virus infections and allergic airway inflammation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2004Article
- Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein.The Journal of experimental medicine · 2003Article
- Altered eosinophil levels as a result of viral infection in asthma exacerbation in childhood.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2002Article
- Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice.Gene therapy · 2001Article
- Immune response induced by airway sensitization after influenza A virus infection depends on timing of antigen exposure in mice.Journal of virology · 2001Article
- Infections prevent the development of asthma--true, false or both?Journal of the Royal Society of Medicine · 1999Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory viral infection is known clinically to promote sensitization to antigen inhalation and the development of asthma.
objectiveThe purpose of this investigation was to determine whether influenza type A virus infection enhances inhalation sensitization and increases airway responsiveness in mice.
methodsMice were infected by intranasal inoculation with influenza A viruses (strains: H1N1 and H3N2) or PBS. Animals were exposed to aerosols of ovalbumin on day 3. Two weeks after ovalbumin sensitization, mice were challenged with ovalbumin aerosols; 24 hours later, airway responsiveness (AR) to inhaled methacholine, levels of ovalbumin-specific IgE, and bronchoalveolar lavage fluid (BALF) were examined.
resultsNeither influenza A virus (H1N1 nor H3N2) alone nor ovalbumin sensitization alone caused changes in AR or IgE. However, ovalbumin sensitization after inoculation with either influenza A virus increased AR and levels of ovalbumin-specific IgE. On BALF-cell analysis, ovalbumin sensitization after inoculation with influenza virus A increased the number of lymphocytes but not the number of eosinophils. No difference in AR or IgE levels was observed between the 2 strains of influenza A viruses. Immmunostaining of BALF cells showed an increase in T cells, especially CD8(+) cells, with ovalbumin sensitization after inoculation with influenza virus A.
conclusionInfection by influenza A virus enhances sensitization to inhaled antigens and airway responsiveness in mice by means of mechanisms including CD8(+) cells and antigen-specific IgE.
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