ArticleJapanese journal of cancer research : Gann1998
Tumor-specific activation of mitogen-activated protein kinase in human colorectal and gastric carcinoma tissues.
Article in Japanese journal of cancer research : Gann, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer.Molecular oncology · 2022Article
- Inhibition of p38 MAPK increases the sensitivity of 5-fluorouracil-resistant SW480 human colon cancer cells to noscapine.Oncology letters · 2022Article
- Cholesteryl butyrate solid lipid nanoparticles inhibit the adhesion and migration of colon cancer cells.British journal of pharmacology · 2012Article
- Prognostic value of RKIP and p-ERK in gastric cancer.Journal of experimental & clinical cancer research : CR · 2012Article
- The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis.Molecular cancer · 2010Article
- Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells.Molecular cancer · 2006Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
To search for the signaling events in colorectal carcinoma relevant to its tumorigenesis, we investigated the activity of mitogen-activated protein kinase (MAPK) in human colorectal carcinoma tissues and paired normal tissues. Of 64 cases examined, approximately 75% (48 cases) showed tumor-specific activation of MAPK by in situ kinase renaturation assay, as well as in vitro kinase assay with immunoprecipitated MAPK. In addition, tumor-specific activation of MAPK was associated with the activation of MAPK kinase in the cases we examined. However, no clear correlation of MAPK activation with lymph node involvement, metastatic rate, stage, histological classification, age or sex was observed. These results suggest that the MAPK pathway is involved in colorectal tumor development, but its activation alone is not sufficient for malignant conversion. In contrast to colorectal carcinoma, gastric carcinoma tissues showed a lower rate of MAPK activation, suggesting that the signaling pathway activated in colorectal carcinoma tissues may differ in part from that of gastric carcinoma.
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