ArticleThe Journal of cell biology1998
Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 83 citations in OpenAlex.
- Liver Organoids: Recent Developments, Limitations and Potential.Frontiers in medicine · 2021Review
- Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis.BMC developmental biology · 2015Article
- The aPKCι blocking agent ATM negatively regulates EMT and invasion of hepatocellular carcinoma.Cell death & disease · 2014Article
- New insights in hepatocellular carcinoma: from bench to bedside.Annals of translational medicine · 2013Review
- Probing the hepatic progenitor cell in human hepatocellular carcinoma.Gastroenterology research and practice · 2013Article
- Growth factor- and cytokine-driven pathways governing liver stemness and differentiation.World journal of gastroenterology · 2010Article
- Progress in stem cell-derived technologies for hepatocellular carcinoma.Stem cells and cloning : advances and applications · 2010Review
- Hepatic progenitors for liver disease: current position.Stem cells and cloning : advances and applications · 2010Review
- Biology of the adult hepatic progenitor cell: "ghosts in the machine".Progress in molecular biology and translational science · 2010Review
- Stem cells and liver regeneration.Gastroenterology · 2009Review
- Stem cells, cell transplantation and liver repopulation.Biochimica et biophysica acta · 2008Review
- Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture.Molecular biology of the cell · 2007Article
- Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Growth of hepatitis A virus in a mouse liver cell line.Journal of virology · 2005Article
- Cell-based assay for the detection of chemically induced cellular stress by immortalized untransformed transgenic hepatocytes.BMC biotechnology · 2004Article
- Article
- Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures.Journal of virology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Met murine hepatocyte (MMH) lines were established from livers of transgenic mice expressing constitutively active human Met. These lines harbor two cell types: epithelial cells resembling the parental populations and flattened cells with multiple projections and a dispersed growth habit that are designated palmate. Epithelial cells express the liver-enriched transcription factors HNF4 and HNF1alpha, and proteins associated with epithelial cell differentiation. Treatments that modulate their differentiation state, including acidic FGF, induce hepatic functions. Palmate cells show none of these properties. However, they can differentiate along the hepatic cell lineage, giving rise to: (a) epithelial cells that express hepatic transcription factors and are competent to express hepatic functions; (b) bile duct-like structures in three-dimensional Matrigel cultures. Derivation of epithelial from palmate cells is confirmed by characterization of the progeny of individually fished cells. Furthermore, karyotype analysis confirms the direction of the phenotypic transition: palmate cells are diploid and the epithelial cells are hypotetraploid. The clonal isolation of the palmate cell, an immortalized nontransformed bipotential cell that does not yet express the liver-enriched transcription factors and is a precursor of the epithelial-hepatocyte in MMH lines, provides a new tool for the study of mechanisms controlling liver development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.