ArticleThe Journal of cell biology1998
Dynamics of axonal microtubules regulate the topology of new membrane insertion into the growing neurites.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor.Cells · 2021Review
- Review
- Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches.Developmental neurobiology · 2016Review
- The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells.Frontiers in plant science · 2014Review
- Article
- Multiple roles for the actin cytoskeleton during regulated exocytosis.Cellular and molecular life sciences : CMLS · 2013Review
- Modeling transport of a pulse of radiolabeled organelles in a Drosophila unipolar motor neuron.Journal of biological physics · 2013Article
- Assembly of a new growth cone after axotomy: the precursor to axon regeneration.Nature reviews. Neuroscience · 2012Review
- Proteomic analysis of Brassica stigmatic proteins following the self-incompatibility reaction reveals a role for microtubule dynamics during pollen responses.Molecular & cellular proteomics : MCP · 2011Article
- The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.The EMBO journal · 2010Article
- Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules.Molecular biology of the cell · 2010Article
- An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.Nature cell biology · 2009Article
- Quantifying neurite growth mediated by interactions among secretory vesicles, microtubules, and actin networks.Biophysical journal · 2009Article
- Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.Traffic (Copenhagen, Denmark) · 2009Article
- Formation of microtubule-based traps controls the sorting and concentration of vesicles to restricted sites of regenerating neurons after axotomy.The Journal of cell biology · 2007Article
- Developmental regulation of sensory axon regeneration in the absence of growth cones.Journal of neurobiology · 2006Article
- Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis.Developmental biology · 2006Article
- A role for synaptotagmin VII-regulated exocytosis of lysosomes in neurite outgrowth from primary sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head.The Journal of cell biology · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Nerve growth depends on the delivery of cell body-synthesized material to the growing neuronal processes. The cellular mechanisms that determine the topology of new membrane addition to the axon are not known. Here we describe a technique to visualize the transport and sites of exocytosis of cell body- derived vesicles in growing axons. We found that in Xenopus embryo neurons in culture, cell body-derived vesicles were rapidly transported all the way down to the growth cone region, where they fused with the plasma membrane. Suppression of microtubule (MT) dynamic instability did not interfere with the delivery of new membrane material to the growth cone region; however, the insertion of vesicles into the plasma membrane was dramatically inhibited. Local disassembly of MTs by focal application of nocodazole to the middle axonal segment resulted in the addition of new membrane at the site of drug application. Our results suggest that the local destabilization of axonal MTs is necessary and sufficient for the delivery of membrane material to specific neuronal sites.
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