ArticleInternational journal of pancreatology : official journal of the International Association of Pancreatology1998
Effects of the polyacetate esters of nutrient and nonnutrient monosaccharides on 45calcium efflux and insulin release from perifused rat pancreatic islets.
Article in International journal of pancreatology : official journal of the International Association of Pancreatology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Inhibitory action of the anomers of 2-deoxy-D-glucose tetraacetate on the metabolism of D-glucose in rat pancreatic islets.International journal of pancreatology : official journal of the International Association of Pancreatology · 2000Article
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4 authors.
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Abstract
conclusionThe polyacetate esters of selected nonnutrient monosaccharides represent potential tools for either stimulation of insulin release in noninsulin-dependent diabetes or inhibition of insulin secretion in hyperinsulinemic syndromes.
backgroundThe polyacetate esters of several monosaccharides were recently shown to display greater nutritional value or biological efficiency than the corresponding unesterified carbohydrates.
methodsThe effects of seven polyacetate esters of monosaccharides, all tested at a 1.7-mM concentration, on both 45Ca efflux and insulin release were investigated in prelabeled rat pancreatic islets perifused in the presence of 10.0 mM succinic acid dimethyl ester.
resultsBoth alpha-D-glucose penta-acetate and, to a lesser extent, beta-L-glucose penta-acetate stimulated insulin release. Inversely, alpha-D-galactose penta-acetate, but not beta-D-galactose penta-acetate inhibited insulin secretion evoked by succinic acid dimethyl ester. Esters of carbohydrates which are inhibitors of D-glucose metabolism, such as D-mannoheptulose hexa-acetate and the two anomers of 2-deoxy-D-glucose tetra-acetate also enhanced insulin output, with a preference for the alpha-anomer of 2-deoxy-D-glucose tetra-acetate. Only those esters with positive insulinotropic action augmented 45Ca efflux from the prelabeled islets.
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