ArticleJournal of the Royal Society of Medicine1998
Relation between depression and circulating immune products in patients with advanced colorectal cancer.
Article in Journal of the Royal Society of Medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Patient-reported outcomes as predictors of survival in patients with bowel cancer: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Pooled it
- Clinical outcomes of neobladder or augmentation after cystectomy in locally advanced colorectal cancer involving urinary tract: case series.BMC urology · 2025Article
- Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies.Experimental & molecular medicine · 2024Review
- Alcohol reshapes a liver premetastatic niche for cancer by extra- and intrahepatic crosstalk-mediated immune evasion.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Patient-Reported Outcomes in Surgical Oncology: An Overview of Instruments and Scores.Annals of surgical oncology · 2020Article
- Mediation analysis of relationships between chronic inflammation and quality of life in older adults.Health and quality of life outcomes · 2016Article
- Ginsenoside Rh2 alleviates tumor-associated depression in a mouse model of colorectal carcinoma.American journal of translational research · 2016Article
- Inflammatory cytokine-associated depression.Brain research · 2015Review
- Proinflammatory cytokines correlate with depression and anxiety in colorectal cancer patients.BioMed research international · 2014Article
- Individual differences in pre-carcinogen cytokine and corticosterone concentrations and depressive-like behavior predict tumor onset in rats exposed to a carcinogen.Psychoneuroendocrinology · 2013Article
- Associations between quality of life, fatigue, and cytokine levels in patients aged 50+ with acute myeloid leukemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2009Article
- Diminished quality of life in patients with cancer correlates with tryptophan degradation.Journal of cancer research and clinical oncology · 2007Article
- Depression in terminally ill patients with cancer.Journal of the Royal Society of Medicine · 2002Article
- Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer.British journal of cancer · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously suggested that colorectal liver metastases might produce 'toxins' that reduce both quality of life (QoL) and survival. In this study we assessed whether QoL in patients with such metastases was related to immune activation, as determined by increased serum levels of interleukin 6 (IL6), soluble tumour necrosis factor receptor 1 (sTNFr1), soluble interleukin 2 receptor alpha (sIL2r alpha) or the interferon-gamma marker neopterin. Serum IL6, sTNFr1, sIL2r alpha, neopterin, alkaline phosphatase and carcinoembryonic antigen levels, liver metastasis volume, and QoL (Hospital Anxiety and Depression [HAD] scale, Rotterdam Symptom Checklist [RSC], and Sickness Impact Profile [SIP]) were measured in 43 patients. There were significant positive correlations between serum sIL2r alpha and HAD depression score (r = 0.66, P = 0.0001), RSC physical symptom score (r = 0.46, P < 0.01), and SIP score (r = 0.47, P = 0.009). Multiple regression analysis suggested that serum sIL2r alpha level was a significant independent predictor of HAD depression score. Although survival was shorter (logrank test P < 0.05) where sIL2r alpha, sTNFr1 and IL6 levels were higher, the ability of sIL2r alpha to predict HAD depression score was independent of survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.