ArticleThe Journal of experimental medicine1998
Permanent CD8(+) T cell depletion prevents proteinuria in active Heymann nephritis.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
- Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury.International journal of molecular sciences · 2023Review
- Predictive Models for Recurrent Membranous Nephropathy After Kidney Transplantation.Transplantation direct · 2022Article
- Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment.Frontiers in immunology · 2022Review
- Identification of Hub Genes and Immune-Related Pathways for Membranous Nephropathy by Bioinformatics Analysis.Frontiers in physiology · 2022Article
- Role of CD8+ T cells in crescentic glomerulonephritis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
- Alloactivation of Naïve CD4Frontiers in immunology · 2019Article
- The Modified Vaccination Technique.Vaccines · 2018Article
- Bowman's capsule provides a protective niche for podocytes from cytotoxic CD8+ T cells.The Journal of clinical investigation · 2018Article
- CD103+ Dendritic Cells Elicit CD8+ T Cell Responses to Accelerate Kidney Injury in Adriamycin Nephropathy.Journal of the American Society of Nephrology : JASN · 2016Article
- T Cells: Soldiers and Spies--The Surveillance and Control of Effector T Cells by Regulatory T Cells.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Computational prediction and experimental assessment of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from neutral endopeptidase.Immunologic research · 2012Article
- CD8+ regulatory T cells induced by T cell vaccination protect against autoimmune nephritis.Journal of the American Society of Nephrology : JASN · 2012Article
- Pathogenic role of effector cells and immunoglobulins in cationic bovine serum albumin-induced membranous nephropathy.Journal of clinical immunology · 2012Article
- Role of T cells and dendritic cells in glomerular immunopathology.Seminars in immunopathology · 2007Review
- Preventative and therapeutic vaccination to combat an experimental autoimmune kidney disease.Biologics : targets & therapy · 2007Article
- Down-regulation of pathogenic autoantibody response in a slowly progressive Heymann nephritis kidney disease model.International journal of experimental pathology · 2004Article
- Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis.The American journal of pathology · 2004Article
- Production of a new model of slowly progressive Heymann nephritis.International journal of experimental pathology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active Heymann nephritis (HN) is a rat model of human idiopathic membranous nephropathy in which injury is thought to be mediated by membrane attack complex of complement (MAC) activated by antibody (Ab) to glomerular epithelial cells. Recent work has shown that HN develops in C6-deficient rats which cannot assemble MAC, and that infiltration of activated cytotoxic CD8(+) T cells and macrophages into glomeruli coincides with proteinuria. This study examined the role of CD8(+) T cells in mediating glomerular injury in HN by permanent CD8(+) cytotoxic T cell depletion via adult thymectomy (ATx) and anti-CD8 mAb. Groups of rats were depleted of CD8(+) T cells either before immunization for HN or 6 wk after immunization when Ab responses and glomerular IgG deposition were well established. These were compared with groups of HN, ATx/HN, and complete Freund's adjuvant (CFA) controls. Neither group of CD8(+) T cell-depleted rats developed proteinuria, although there was normal development and deposition of Ab. CD8(+) T cell-depleted rats developed neither T cell or macrophage infiltrates nor their effector cytokines, which are present in glomeruli of rats with HN. Examination of lymph node (LN) draining sites of immunization showed these findings were not explained by altered immune events within these LNs. It was concluded that CD8(+) cytotoxic T cells are essential to the mediation of glomerular injury in HN and may be relevant to the pathogenesis and treatment of membranous nephropathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.