ArticleRNA (New York, N.Y.)1998
cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5' nontranslated region chimeras.
Article in RNA (New York, N.Y.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- First full-genome alignment representative for the genusRNA (New York, N.Y.) · 2026Article
- TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection.Journal of virology · 2017Article
- Article
- Modulation of translation initiation efficiency in classical swine fever virus.Journal of virology · 2012Article
- Cis-acting structural element in 5' UTR is essential for infectivity of porcine reproductive and respiratory syndrome virus.Virus research · 2012Article
- Article
- Nuclear factors are involved in hepatitis C virus RNA replication.RNA (New York, N.Y.) · 2007Article
- A distinct group of hepacivirus/pestivirus-like internal ribosomal entry sites in members of diverse picornavirus genera: evidence for modular exchange of functional noncoding RNA elements by recombination.Journal of virology · 2007Article
- Essential and nonessential elements in the 3' nontranslated region of Bovine viral diarrhea virus.Journal of virology · 2005Article
- Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication.Journal of virology · 2005Article
- Origination and consequences of bovine viral diarrhea virus diversity.The Veterinary clinics of North America. Food animal practice · 2004Review
- Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus.Journal of virology · 2004Article
- Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication.Journal of virology · 2004Article
- Hep3B human hepatoma cells support replication of the wild-type and a 5'-end deletion mutant GB virus B replicon.Journal of virology · 2003Article
- Significance in replication of the terminal nucleotides of the flavivirus genome.Journal of virology · 2003Article
- Role of the 5'-proximal stem-loop structure of the 5' untranslated region in replication and translation of hepatitis C virus RNA.Journal of virology · 2003Article
- 3' nontranslated RNA signals required for replication of hepatitis C virus RNA.Journal of virology · 2003Article
- Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.Journal of virology · 2001Article
- Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity.Journal of virology · 2001Article
- Efficient translation initiation is required for replication of bovine viral diarrhea virus subgenomic replicons.Journal of virology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pestiviruses, such as bovine viral diarrhea virus (BVDV), share many similarities with hepatitis C virus (HCV) yet are more amenable to virologic and genetic analysis. For both BVDV and HCV, translation is initiated via an internal ribosome entry site (IRES). Besides IRES function, the viral 5' nontranslated regions (NTRs) may also contain cis-acting RNA elements important for viral replication. A series of chimeric RNAs were used to examine the function of the BVDV 5' NTR. Our results show that: (1) the HCV and the encephalomyocarditis virus (EMCV) IRES element can functionally replace that of BVDV; (2) two 5' terminal hairpins in BVDV genomic RNA are important for efficient replication; (3) replacement of the entire BVDV 5' NTR with those of HCV or EMCV leads to severely impaired replication; (4) such replacement chimeras are unstable and efficiently replicating pseudorevertants arise; (5) pseudorevertant mutations involve deletion of 5' sequences and/or acquisition of novel 5' sequences such that the 5' terminal 3-4 bases of BVDV genome RNA are restored. Besides providing new insight into functional elements in the BVDV 5' NTR, these chimeras may prove useful as pestivirus vaccines and for screening and evaluation of anti-HCV IRES antivirals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.