Evidence map›Paper›PMID 9812929›Full record

ArticleBMJ (Clinical research ed.)1998

Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study.

F B Hu, M J Stampfer, J E Manson, E B Rimm, G A Colditz, B A Rosner, F E Speizer, C H Hennekens, W C Willett

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005152 active not recruitingnot on this map

Nurses' Health Study (Cardiovascular Component)

TypeobservationalSponsorBrigham and Women's HospitalRan1980 to 2029Enrolled121,700ConditionsCardiovascular Diseases, Diabetes Mellitus, Coronary Disease, Heart Diseases
NCT02078635 nawithdrawnnot on this map

The Canada-wide Human Nutrition Trialists' Network

TypeinterventionalSponsorUnity Health TorontoEnrolled0ConditionsCardiovascular Diseases, Hypercholesterolemia, Diabetes, Metabolic SyndromeArmsPortfolio Plus Diet, DASH-like (high fibre) dietary advice
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

F B HuDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. Frank.Hu@channing.harvard.edu
M J Stampfer
J E Manson
E B Rimm
G A Colditz
B A Rosner
F E Speizer
C H Hennekens
W C Willett

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
TRAINING GRANT IN ACADEMIC NUTRITIONT32DK007703 · NIDDK · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTOPHER P DUGGAN, Frank B Hu · 1994 to 2026
$7.8M
PROSPECTIVE STUDY OF DIET AND CANCER IN WOMENR01CA040356 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI SPEIZER, FRANK E · 1985 to 2000
$824k
PROSPECTIVE STUDY OF DIET AND CANCER IN WOMENR37CA040356 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI SPEIZER, FRANK E · 1987 to 1994
–
NCI NIH HHS CA40356NCI NIH HHS R01 CA040356NHLBI NIH HHS HL24074NHLBI NIH HHS HL34594NHLBI NIH HHS R01 HL034594NIDDK NIH HHS P30 DK046200NIDDK NIH HHS T32 DK007703
6 · The paper itself

Abstract

objectiveTo examine the relation between nut consumption and risk of coronary heart disease in a cohort of women from the Nurses' Health Study.

designProspective cohort study.

settingNurses' Health Study. SUBJECTS: 86 016 women from 34 to 59 years of age without previously diagnosed coronary heart disease, stroke, or cancer at baseline in 1980.

main outcome measuresMajor coronary heart disease including non-fatal myocardial infarction and fatal coronary heart disease.

results1255 major coronary disease events (861 cases of non-fatal myocardial infarction and 394 cases of fatal coronary heart disease) occurred during 14 years of follow up. After adjusting for age, smoking, and other known risk factors for coronary heart disease, women who ate more than five units of nuts (one unit equivalent to 1 oz of nuts) a week (frequent consumption) had a significantly lower risk of total coronary heart disease (relative risk 0.65, 95% confidence interval 0.47 to 0.89, P for trend=0.0009) than women who never ate nuts or who ate less than one unit a month (rare consumption). The magnitude of risk reduction was similar for both fatal coronary heart disease (0.61, 0.35 to 1.05, P for trend=0.007) and non-fatal myocardial infarction (0.68, 0.47 to 1.00, P for trend=0.04). Further adjustment for intakes of dietary fats, fibre, vegetables, and fruits did not alter these results. The inverse association persisted in subgroups stratified by levels of smoking,use of alcohol, use of multivitamin and vitamin E supplements, body mass index, exercise, and intake of vegetables or fruits.

conclusionsFrequent nut consumption was associated with a reduced risk of both fatal coronary heart disease and non-fatal myocardial infarction. These data, and those from other epidemiological and clinical studies, support a role for nuts in reducing the risk of coronary heart disease.

Indexed as

NutsAdultCohort StudiesCoronary DiseaseDietFemaleFollow-Up StudiesHumansIncidenceMiddle AgedMyocardial InfarctionProspective StudiesRisk FactorsUnited States

Identifiers

PMID9812929
PMCPMC28714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.