ArticleInfectious diseases in obstetrics and gynecology1998
17-beta-estradiol upregulates the stress response in Candida albicans: implications for microbial virulence.
Article in Infectious diseases in obstetrics and gynecology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Differential Gene Expression of Heat Shock Protein 90 (Hsp90) of Candida albicans obtained from Malaysian and Iranian Patients.The Malaysian journal of medical sciences : MJMS · 2016Article
- Animal models of mucosal Candida infection.FEMS microbiology letters · 2008Review
- Tetracycline effects on Candida albicans virulence factors.Infectious diseases in obstetrics and gynecology · 2008Article
- A genome-wide steroid response study of the major human fungal pathogen Candida albicans.Mycopathologia · 2007Article
- Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity.Infection and immunity · 2004Article
- Isolation and identification of a 92-kDa stress induced protein from Candida albicans.Mycopathologia · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe influence of 17-beta-estradiol on the stress response of Candida albicans was studied.
methodsThe survival of clinical isolates of C. albicans treated with 17-beta-estradiol after heat and oxidative stress was measured by viable plate counts. Cellular proteins were analyzed via SDS-PAGE.
resultsThe heat stress response induced by 17-beta-estradiol in C. albicans grown at 25 degrees C protected the organisms against the lethal temperature of 48.5 degrees C, as shown by viable plate counts. 17-beta-estradiol also enhanced protection of C. albicans against oxidative stress (menadione exposure). SDS-PAGE analysis of cytoplasmic extracts revealed proteins induced by 17-beta-estradiol were similar to those induced by heat.
conclusion17-beta-estradiol enhances survival of C. albicans under heat and oxidative stresses. The proteins induced by 17-beta-estradiol are probably heat shock proteins. Because heat shock proteins are considered to be virulence factors, 17-beta-estradiol may function to promote in vivo survival.
Indexed as
Identifiers
9812250PMC1784798W2158856360What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.