ArticleProceedings of the National Academy of Sciences of the United States of America1998
Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- Review
- Oxidative Stress and Lymphocyte Alterations in Chronic Relapsing Experimental Allergic Encephalomyelitis in the Rat Hippocampus and Protective Effects of an Ethanolamine Phosphate Salt.Molecular neurobiology · 2020Article
- Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update.Oxidative medicine and cellular longevity · 2020Review
- Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis.Oxidative medicine and cellular longevity · 2017Article
- Adeno-associated virus mediated SOD gene therapy protects the retinal ganglion cells from chronic intraocular pressure elevation induced injury via attenuating oxidative stress and improving mitochondrial dysfunction in a rat model.American journal of translational research · 2016Article
- Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAE.Investigative ophthalmology & visual science · 2015Article
- Retinal gene therapy using adeno-associated viral vectors: multiple applications for a small virus.Human gene therapy · 2014Article
- Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.Investigative ophthalmology & visual science · 2014Article
- Ability of recombinant human catalase to suppress inflammation of the murine lung induced by influenza A.Inflammation · 2014Article
- PEGylated human catalase elicits potent therapeutic effects on H1N1 influenza-induced pneumonia in mice.Applied microbiology and biotechnology · 2013Article
- Mitochondria-targeted antiaging gene therapy with adeno-associated viral vectors.Methods in molecular biology (Clifton, N.J.) · 2013Article
- The insulin-like growth factor 1 receptor is essential for axonal regeneration in adult central nervous system neurons.PloS one · 2013Article
- In vivo detection of experimental optic neuritis by pupillometry.Experimental eye research · 2012Article
- Article
- Analysis of the pathogenesis of experimental autoimmune optic neuritis.Journal of biomedicine & biotechnology · 2011Article
- Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.Scientific reports · 2011Article
- Oral resveratrol reduces neuronal damage in a model of multiple sclerosis.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2010Article
- Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina.Molecular vision · 2009Article
- Channelrhodopsins provide a breakthrough insight into strategies for curing blindness.Journal of genetics · 2009Review
- Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature.Investigative ophthalmology & visual science · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Suppression of oxidative injury by viral-mediated transfer of the human catalase gene was tested in the optic nerves of animals with experimental allergic encephalomyelitis (EAE). EAE is an inflammatory autoimmune disorder of primary central nervous system demyelination that has been frequently used as an animal model for the human disease multiple sclerosis (MS). The optic nerve is a frequent site of involvement common to both EAE and MS. Recombinant adeno-associated virus containing the human gene for catalase was injected over the right optic nerve heads of SJL/J mice that were simultaneously sensitized for EAE. After 1 month, cell-specific catalase activity, evaluated by quantitation of catalase immunogold, was increased approximately 2-fold each in endothelia, oligodendroglia, astrocytes, and axons of the optic nerve. Effects of catalase on the histologic lesions of EAE were measured by computerized analysis of the myelin sheath area (for demyelination), optic disc area (for optic nerve head swelling), extent of the cellular infiltrate, extravasated serum albumin labeled by immunogold (for blood-brain barrier disruption), and in vivo H2O2 reaction product. Relative to control, contralateral optic nerves injected with the recombinant virus without a therapeutic gene, catalase gene inoculation reduced demyelination by 38%, optic nerve head swelling by 29%, cellular infiltration by 34%, disruption of the blood-brain barrier by 64%, and in vivo levels of H2O2 by 61%. Because the efficacy of potential treatments for MS are usually initially tested in the EAE animal model, this study suggests that catalase gene delivery by using viral vectors may be a therapeutic strategy for suppression of MS.
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