ArticleProceedings of the National Academy of Sciences of the United States of America1998
An HP1-like protein is missing from transcriptionally silent micronuclei of Tetrahymena.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Functions of HP1 proteins in transcriptional regulation.Epigenetics & chromatin · 2022Review
- Functional Proteomics of Nuclear Proteins inGenes · 2019Review
- Diversification of HP1-like Chromo Domain Proteins in Tetrahymena thermophila.The Journal of eukaryotic microbiology · 2018Article
- RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena.Genes & development · 2007Article
- The condensin complex is essential for amitotic segregation of bulk chromosomes, but not nucleoli, in the ciliate Tetrahymena thermophila.Molecular and cellular biology · 2006Article
- Class I histone deacetylase Thd1p affects nuclear integrity in Tetrahymena thermophila.Eukaryotic cell · 2005Article
- A Dicer-like protein in Tetrahymena has distinct functions in genome rearrangement, chromosome segregation, and meiotic prophase.Genes & development · 2005Article
- Spatiotemporal sites of DNA replication in macro- and micronuclei of the ciliate Paramecium caudatum.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003Article
- Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin.The Journal of cell biology · 2002Article
- Versatility of conviction: heterochromatin as both a repressor and an activator of transcription.Genetica · 2000Article
- A nuclear protein involved in apoptotic-like DNA degradation in Stylonychia: implications for similar mechanisms in differentiating and starved cells.Molecular biology of the cell · 1999Article
- A nonessential HP1-like protein affects starvation-induced assembly of condensed chromatin and gene expression in macronuclei of Tetrahymena thermophila.Molecular and cellular biology · 1999Article
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4 authors at 3 institutions in 1 country.
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Abstract
We report the identification and cloning of a 28-kDa polypeptide (p28) in Tetrahymena macronuclei that shares several features with the well studied heterochromatin-associated protein HP1 from Drosophila. Notably, like HP1, p28 contains both a chromodomain and a chromoshadow domain. p28 also shares features with linker histone H1, and like H1, p28 is multiply phosphorylated, at least in part, by a proline-directed, Cdc2-type kinase. As such, p28 is referred to as Hhp1p (for H1/HP1-like protein). Hhp1p is missing from transcriptionally silent micronuclei but is enriched in heterochromatin-like chromatin bodies that presumably comprise repressed chromatin in macronuclei. These findings shed light on the evolutionary conserved nature of heterochromatin in organisms ranging from ciliates to humans and provide further evidence that HP1-like proteins are not exclusively associated with permanently silent chromosomal domains. Our data support a view that members of this family also associate with repressed states of euchromatin.
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