ArticleProceedings of the National Academy of Sciences of the United States of America1998
Electrostatic interaction between helical macromolecules in dense aggregates: an impetus for DNA poly- and meso-morphism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Helical correlations in curved DNA condensates.Nucleic acids research · 2025Article
- Article
- Local structure of DNA toroids reveals curvature-dependent intermolecular forces.Nucleic acids research · 2021Article
- Role of Disulfide Bonds on DNA Packaging Forces in Bull Sperm Chromatin.Biophysical journal · 2017Article
- Order and interactions in DNA arrays: Multiscale molecular dynamics simulation.Scientific reports · 2017Article
- Does Cation Size Affect Occupancy and Electrostatic Screening of the Nucleic Acid Ion Atmosphere?Journal of the American Chemical Society · 2016Article
- Multi-shell model of ion-induced nucleic acid condensation.The Journal of chemical physics · 2016Article
- Trapping and Driving Individual Charged Micro-particles in Fluid with an Electrostatic Device.Nano-micro letters · 2016Article
- Close encounters with DNA.Journal of physics. Condensed matter : an Institute of Physics journal · 2014Review
- An experimentally-informed coarse-grained 3-Site-Per-Nucleotide model of DNA: structure, thermodynamics, and dynamics of hybridization.The Journal of chemical physics · 2013Article
- Supramolecular Assembly of DNA on Graphene Nanoribbons.Journal of materials chemistry. B · 2013Article
- Structure-driven homology pairing of chromatin fibers: the role of electrostatics and protein-induced bridging.Journal of biological physics · 2013Article
- Helical structure determines different susceptibilities of dsDNA, dsRNA, and tsDNA to counterion-induced condensation.Biophysical journal · 2013Article
- A comparison of DNA compaction by arginine and lysine peptides: a physical basis for arginine rich protamines.Biochemistry · 2013Article
- DNA self-assembly: from chirality to evolution.International journal of molecular sciences · 2013Review
- Cation charge dependence of the forces driving DNA assembly.Biophysical journal · 2010Article
- Undulations enhance the effect of helical structure on DNA interactions.The journal of physical chemistry. B · 2010Article
- Differential stability of DNA crossovers in solution mediated by divalent cations.Nucleic acids research · 2010Article
- Chain and conformation stability of solid-state DNA: implications for room temperature storage.Nucleic acids research · 2010Article
- Symmetry of electrostatic interaction between pyrophosphate DNA molecules.The European physical journal. E, Soft matter · 2010Article
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2 authors.
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Abstract
DNA exhibits a surprising multiplicity of structures when it is packed into dense aggregates. It undergoes various polymorphous transitions (e.g., from the B to A form) and mesomorphous transformations (from hexagonal to orthorhombic or monoclinic packing, changes in the mutual alignment of nearest neighbors, etc). In this report we show that such phenomena may have their origin in the specific helical symmetry of the charge distribution on DNA surface. Electrostatic interaction between neighboring DNA molecules exhibits strong dependence on the patterns of molecular surface groups and adsorbed counter-ions. As a result, it is affected by such structural parameters as the helical pitch, groove width, the number of base pairs per helical turn, etc. We derive expressions which relate the energy of electrostatic interaction with these parameters and with the packing variables characterizing the axial and azimuthal alignment between neighboring macromolecules. We show, in particular, that the structural changes upon the B-to-A transition reduce the electrostatic energy by approximately kcal/mol per base pair, at a random adsorption of counter ions. Ion binding into the narrow groove weakens or inverts this effect, stabilizing B-DNA, as it is presumably the case in Li+-DNA assemblies. The packing symmetry and molecular alignment in DNA aggregates are shown to be affected by the patterns of ion binding.
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