ArticleThe Plant cell1998
Nuclear localization signal receptor importin alpha associates with the cytoskeleton.
Article in The Plant cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- RIP at the Synapse and the Role of Intracellular Domains in Neurons.Neuromolecular medicine · 2020Review
- Importins α and β signaling mediates endothelial cell inflammation and barrier disruption.Cellular signalling · 2018Article
- Looking beyond the Wnt pathway for the deep nature of β-catenin.EMBO reports · 2013Review
- Proteomic and functional analyses of protein-DNA complexes during gene transfer.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells.PloS one · 2013Article
- Cellulose synthase interactive protein 1 (CSI1) mediates the intimate relationship between cellulose microfibrils and cortical microtubules.Plant signaling & behavior · 2012Article
- Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The Arabidopsis nuclear pore and nuclear envelope.The arabidopsis book · 2010Article
- The intracellular mobility of nuclear import receptors and NLS cargoes.Biophysical journal · 2009Article
- Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4.The EMBO journal · 2008Article
- Dynein light chain association sequences can facilitate nuclear protein import.Molecular biology of the cell · 2007Article
- Significant proportions of nuclear transport proteins with reduced intracellular mobilities resolved by fluorescence correlation spectroscopy.Journal of molecular biology · 2007Article
- Inositol 1,4,5-trisphosphate and Ran expression during simulated and real microgravity.Protoplasma · 2006Article
- Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmic movement and nuclear import.Current gene therapy · 2006Review
- Article
- Nuclear localization signal peptides induce molecular delivery along microtubules.Biophysical journal · 2005Article
- Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling.Current genetics · 2003Review
- Localization of importin alpha (Rch1) at the plasma membrane and subcellular redistribution during lymphocyte activation.Chromosoma · 2003Article
- Characterization of AtCDC48. Evidence for multiple membrane fusion mechanisms at the plane of cell division in plants.Plant physiology · 2002Article
- A 90-kD phospholipase D from tobacco binds to microtubules and the plasma membrane.The Plant cell · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importin alpha is the nuclear localization signal (NLS) receptor that is involved in the nuclear import of proteins containing basic NLSs. Using importin alpha as a tool, we were interested in determining whether the cytoskeleton could function in the transport of NLS-containing proteins from the cytoplasm to the nucleus. Double-labeling immunofluorescence studies showed that most of the cytoplasmic importin alpha coaligned with microtubules and microfilaments in tobacco protoplasts. Treatment of tobacco protoplasts with microtubule- or microfilament-depolymerizing agents disrupted the strands of importin alpha in the cytoplasm, whereas a microtubule-stabilizing agent had no effect. Biochemical analysis showed that importin alpha associated with microtubules and microfilaments in vitro in an NLS-dependent manner. The interaction of importin alpha with the cytoskeleton could be an essential element of protein transport from the cytoplasm to the nucleus in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.