ArticleJournal of bacteriology1998
mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 108 citations in OpenAlex.
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- The efflux pumps Rv1877 and Rv0191 play differential roles in the protection ofFrontiers in microbiology · 2024Article
- Penetration of Triphenylphosphonium Derivatives through the Cell Envelope of Bacteria ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Complete genome assembly of Hawai'i environmental nontuberculous mycobacteria reveals unexpected co-isolation with methylobacteria.PloS one · 2023Article
- Critical discussion on drug efflux in Mycobacterium tuberculosis.FEMS microbiology reviews · 2022Review
- Mechanism of drug resistance in bacteria: efflux pump modulation for designing of new antibiotic enhancers.Folia microbiologica · 2021Review
- Targeting redox heterogeneity to counteract drug tolerance in replicatingScience translational medicine · 2019Article
- Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.Antimicrobial agents and chemotherapy · 2019Article
- The prominent alteration in transcriptome and metabolome of Mycobacterium bovis BCG str. Tokyo 172 induced by vitamin BBMC microbiology · 2019Article
- Structure of theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Insights onFrontiers in microbiology · 2018Article
- Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates ofFrontiers in microbiology · 2017Article
- New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria.Frontiers in microbiology · 2017Review
- Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates.PloS one · 2015Article
- Energy metabolism and drug efflux in Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2014Review
- Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.Protein science : a publication of the Protein Society · 2014Article
- Role of the Mmr efflux pump in drug resistance in Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.
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Registered trials
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