ArticleThe American journal of pathology1998
Patterns of chromosomal imbalances in advanced urinary bladder cancer detected by comparative genomic hybridization.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Loss of chromosome Y is unrelated to the composition of the tumor microenvironment and patient prognosis in muscle-invasive urothelial bladder cancers.BMC cancer · 2025Article
- GATA3 amplification is associated with high grade disease in non-invasive urothelial bladder cancer but unrelated to patient prognosis.BMC urology · 2025Article
- Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer.The journal of pathology. Clinical research · 2025Article
- CEA (CEACAM5) expression is common in muscle-invasive urothelial carcinoma of the bladder but unrelated to the disease course.BJUI compass · 2024Article
- Relationship between the genetic expression of WTAP and bladder cancer and patient prognosis.Oncology letters · 2018Article
- Canine urothelial carcinoma: genomically aberrant and comparatively relevant.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- Molecular biology of bladder cancer.Hematology/oncology clinics of North America · 2015Review
- Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA.Journal of translational medicine · 2013Article
- Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
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- Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma.PloS one · 2012Article
- Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations.Carcinogenesis · 2011Article
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- Urine and bladder washing cytology for detection of urothelial carcinoma: standard test with new possibilities.Radiology and oncology · 2010Article
- Expression of pRb, p53, p16 and cyclin D1 and their clinical implications in urothelial carcinoma.Journal of Korean medical science · 2010Article
- Molecular pathogenesis of bladder cancer.International journal of clinical oncology · 2008Review
- Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors.BMC medical genomics · 2008Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify genetic changes linked to bladder cancer progression we analyzed 90 invasive transitional cell carcinomas (37 pT1 and 53 pT2-4) by comparative genomic hybridization. The most frequent alterations included 1q+ (37%), 5p+ (24%), 6q- (19%), 8p-(29%), 8q+ (37%), 9p- (31%), 9q- (23%), 11p-(24%), 11q- (22%), 17q+ (29%), and 20q+ (28%). Interestingly, there were three groups of alterations that frequently occurred together (9p- and 11q13+/ 20q+ and 11q13+ or 17q+/1q+ and 3p+ or 11q-). These loci might carry genes that interact with each other in specific molecular pathways. There were remarkable genetic similarities between minimally and deeply invasive tumors of different histological grades, including a similar number of aberrations per tumor and an equal frequency of most individual alterations. However, deletions of 5q, 6q, and 15q and gains of 5p, 7p, and Xq were significantly more frequent in pT2-4 than in pT1 carcinomas. These loci may harbor genes that are important for bladder cancer progression.
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