ArticleThe American journal of pathology1998
Human keratinocytes express cellular prion-related protein in vitro and during inflammatory skin diseases.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Genetic variability of the prion protein gene (PRNP) in thin-tailed and fat-tailed sheep.Open veterinary journal · 2025Article
- The Multifaceted Functions of Prion Protein (PrPCancers · 2023Review
- PIWIL-2 and piRNAs are regularly expressed in epithelia of the skin and their expression is related to differentiation.Archives of dermatological research · 2020Article
- Transgene Biocontainment Strategies for Molecular Farming.Frontiers in plant science · 2020Review
- Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer's Disease.Virologica Sinica · 2019Review
- Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment.Oncotarget · 2015Article
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- Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.The Journal of biological chemistry · 2010Article
- The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers.Biomarkers in medicine · 2010Article
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- Expression of cellular prion protein (PrP(c)) in schizophrenia, bipolar disorder, and depression.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- Accumulation of pathological prion protein PrPSc in the skin of animals with experimental and natural scrapie.PLoS pathogens · 2007Article
- Developmental expression of PrP in the post-implantation embryo.Brain research · 2007Article
- Expression of the prion protein gene (PRNP) and cellular prion protein (PrPc) in cattle and sheep fetuses and maternal tissues during pregnancy.Gene expression · 2007Article
- Prion protein accumulation and neuroprotection in hypoxic brain damage.The American journal of pathology · 2004Article
- Vaccinia virus pathogenicity in atopic dermatitis is caused by allergen-induced immune response that prevents the antiviral cellular and humoral immunity.Virus genes · 2003Review
- Epithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prion diseases are transmissible spongiform encephalopathies of humans and animals characterized by the accumulation of a proteinase-resistant isoform of the cellular prion-related protein (PrPc) within the central nervous system. In the present report we demonstrate for the first time the presence of PrPc on squamous epithelia of normal and diseased human skin and show that inflammatory cytokines regulate PrPc expression in cultured human keratinocytes (KCs). By immunohistochemistry, only little expression of PrPc, which was mainly confined to KCs, was detected in normal skin. In contrast, in inflammatory skin diseases including psoriasis and contact dermatitis, PrPc was strongly present on both KCs and infiltrating mononuclear cells. Strong PrPc expression was also observed in squamous cell carcinomas and viral warts whereas basal cell carcinomas were mostly negative. In mucous membranes of the upper digestive tract and the genital region, distinct PrPc expression by basal squamous epithelial cells was a constant feature. In tissue culture, primary KCs constitutively expressed PrPc mRNA and protein. Exposure of these cells to transforming growth factor (TGF)-alpha or interferon (IFN)-gamma led to an increase of PrPc protein expression. The presence of PrPc on epithelial cells of skin and mucous membranes suggests that these cells represent possible first targets for peripheral infection with prions.
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