ArticleThe Journal of physiology1998
Relations between intracellular Ca2+ stores and store-operated Ca2+ entry in primary cultured human glioblastoma cells.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
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- Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.iScience · 2025Article
- The Role of Mitochondrial Dysfunction and Inflammatory Response in the Pathogenesis of Sepsis-Induced Myocardial Injury: A Mechanistic Study.Journal of inflammation research · 2025Review
- Drp1/p53 interaction mediates p53 mitochondrial localization and dysfunction in septic cardiomyopathy.Journal of molecular and cellular cardiology · 2023Article
- Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders.Current neuropharmacology · 2023Review
- The CaMKII/MLC1 Axis Confers CaCells · 2022Article
- ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments.Cell death & disease · 2022Review
- Mitochondrial Calcium: Effects of Its Imbalance in Disease.Antioxidants (Basel, Switzerland) · 2022Review
- STIM and ORAI proteins in the nervous system.Channels (Austin, Tex.) · 2015Review
- Store-operated calcium entry in neuroglia.Neuroscience bulletin · 2014Review
- TRP channels coordinate ion signalling in astroglia.Reviews of physiology, biochemistry and pharmacology · 2014Review
- Purinergic signalling and cancer.Purinergic signalling · 2013Review
- TRPC1-mediated Ca2+ and Na+ signalling in astroglia: differential filtering of extracellular cations.Cell calcium · 2013Article
- Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein.American journal of physiology. Cell physiology · 2011Article
- Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.Brain research · 2010Article
- Calcium-sensing receptor in cancer: good cop or bad cop?Endocrine · 2009Review
- Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane.The Journal of physiology · 2003Article
- Energized mitochondria increase the dynamic range over which inositol 1,4,5-trisphosphate activates store-operated calcium influx.The EMBO journal · 2001Article
- Control of Ca2+ influx in human neutrophils by inositol 1,4,5-trisphosphate (IP3) binding: differential effects of micro-injected IP3 receptor antagonists.The Biochemical journal · 2001Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In primary cultured human glioblastoma cells extracellular application of ATP triggered elevation in cytoplasmic calcium concentration ([Ca2+]i) mediated entirely by generation of inositol 1,4,5-trisphosphate (InsP3)-dependent Ca2+ release from endoplasmic reticulum Ca2+ stores followed by the activation of store-operated Ca2+ entry into the cells. 2. Sensitivity of P2Y purinoceptors to extracellular ATP was regulated by extracellular Ca2+: in Ca2+-free extracellular solution the threshold concentration of ATP that induced an increase in [Ca2+]i was reduced by one order of magnitude. 3. Activation of Ca2+ release and store-operated Ca2+ entry was dissociated: low concentrations of ATP induced substantial Ca2+ release without activation of Ca2+ entry; activation of the latter required higher ATP concentrations. 4. Mitochondria participated in buffering Ca2+ loads that resulted from store-operated Ca2+ influx; in contrast Ca2+ released from intracellular stores was not accumulated by the mitochondrial depot. 5. We conclude that ATP-induced Ca2+ responses are governed by several pathways with different sensitivities to the agonist. This enables cells to respond either with pure Ca2+ release from intracellular stores (at low ATP concentrations) or (at high ATP concentrations) the response is amplified by plasmalemmal Ca2+ influx. Store-operated Ca2+ entry increases mitochondrial Ca2+ content providing a link between cellular activation and mitochondrial function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.