ArticleThe Journal of physiology1998
Membrane-limited expression and regulation of Na+-H+ exchanger isoforms by P2 receptors in the rat submandibular gland duct.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 72 citations in OpenAlex.
- SLC9 Gene Family: Function, Expression, and Regulation.Comprehensive Physiology · 2018Review
- The Balance of [Formula: see text] Secretion vs. Reabsorption in the Endometrial Epithelium Regulates Uterine Fluid pH.Frontiers in physiology · 2018Article
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- Different rate-limiting activities of intracellular pH regulators for HCOThe journal of physiological sciences : JPS · 2016Article
- Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1).The Journal of biological chemistry · 2014Article
- Purinergic signalling in the gastrointestinal tract and related organs in health and disease.Purinergic signalling · 2014Review
- Receptor-independent effects of 2'(3')-O-(4-benzoylbenzoyl)ATP triethylammonium salt on cytosolic pH.Purinergic signalling · 2013Article
- Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.Gastroenterology · 2013Article
- A quantitative analysis of electrolyte exchange in the salivary duct.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland.The Journal of physiology · 2010Article
- Purinergic receptors and gastrointestinal secretomotor function.Purinergic signalling · 2008Article
- H+ and HCO3- transporters in human salivary ducts. An immunohistochemical study.The Histochemical journal · 2001Article
- Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct.The Journal of clinical investigation · 2000Article
- Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule.The Journal of clinical investigation · 2000Article
- Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice.The Journal of physiology · 2000Article
- Na(+)-H(+) exchange in salivary secretory cells is controlled by an intracellular Na(+) receptor.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
1. Cell-specific reverse transcriptase-polymerase chain reaction (RT-PCR), immunolocalization and microspectrofluorometry were used to identify and localize the Na+-H+ exchanger (NHE) isoforms expressed in the submandibular gland (SMG) acinar and duct cells and their regulation by basolateral and luminal P2 receptors in the duct. 2. The molecular and immunofluorescence analysis showed that SMG acinar and duct cells expressed NHE1 in the basolateral membrane (BLM). Duct cells also expressed NHE2 and NHE3 in the luminal membrane (LM). 3. Expression of NHE3 was unequivocally established by the absence of staining in SMG from NHE3 knockout mice. NHE3 was expressed in the LM and in subluminal regions of the duct. 4. Measurement of the inhibition of NHE activity by the amiloride analogue HOE 694 (HOE) suggested expression of NHE1-like activity in the BLM and NHE2-like activity in the LM of the SMG duct. Several acute and chronic treatments tested failed to activate NHE activity with low affinity for HOE as expected for NHE3. Hence, the physiological function and role of NHE3 in the SMG duct is not clear at present. 5. Activation of P2 receptors resulted in activation of an NHE-independent, luminal H+ transport pathway that markedly and rapidly acidified the cells. This pathway could be blocked by luminal but not basolateral Ba2+. 6. Stimulation of P2U receptors expressed in the BLM activated largely NHE1-like activity, and stimulation of P2Z receptors expressed in the LM activated largely NHE2-like activity. 7. The interrelation between basolateral and luminal NHE activities and their respective regulation by P2U and P2Z receptors can be used to co-ordinate membrane transport events in the LM and BLM during active Na+ reabsorption by the SMG duct.
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