ArticleThe Journal of general physiology1998
Submaximal responses in calcium-triggered exocytosis are explained by differences in the calcium sensitivity of individual secretory vesicles.
Article in The Journal of general physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Unbiased Thiol-Labeling and Top-Down Proteomic Analyses Implicate Multiple Proteins in the Late Steps of Regulated Secretion.Proteomes · 2019Article
- Unraveling the mechanisms of calcium-dependent secretion.The Journal of general physiology · 2019Review
- Application of High-Throughput Assays to Examine Phospho-Modulation of the Late Steps of Regulated Exocytosis.High-throughput · 2017Article
- The Role of Phospholipase D in Regulated Exocytosis.The Journal of biological chemistry · 2015Article
- Quantification of exocytosis kinetics by DIC image analysis of cortical lawns.Journal of chemical biology · 2014Article
- A new approach to the molecular analysis of docking, priming, and regulated membrane fusion.Journal of chemical biology · 2011Article
- Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion.Journal of physiology and biochemistry · 2010Review
- Enhancement of the Ca(2+)-triggering steps of native membrane fusion via thiol-reactivity.Journal of chemical biology · 2009Article
- Specific lipids supply critical negative spontaneous curvature--an essential component of native Ca2+-triggered membrane fusion.Biophysical journal · 2008Article
- A mechanism intrinsic to the vesicle fusion machinery determines fast and slow transmitter release at a large CNS synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Evidence that rabies virus forms different kinds of fusion machines with different pH thresholds for fusion.Journal of virology · 2004Article
- Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held.The Journal of physiology · 2003Article
- A highly Ca2+-sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Calcium secretion coupling at calyx of Held governed by nonuniform channel-vesicle topography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The actions of barium and strontium on exocytosis and endocytosis in the synaptic terminal of goldfish bipolar cells.The Journal of physiology · 2001Article
- A kinetic analysis of calcium-triggered exocytosis.The Journal of general physiology · 2001Article
- Synaptic depression and the kinetics of exocytosis in retinal bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Sea urchin egg preparations as systems for the study of calcium-triggered exocytosis.The Journal of physiology · 1999Review
- Biochemical and functional studies of cortical vesicle fusion: the SNARE complex and Ca2+ sensitivity.The Journal of cell biology · 1998Article
- The calcium sensitivity of individual secretory vesicles is invariant with the rate of calcium delivery.The Journal of general physiology · 1998Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A graded response to calcium is the defining feature of calcium-regulated exocytosis. That is, there exist calcium concentrations that elicit submaximal exocytotic responses in which only a fraction of the available population of secretory vesicles fuse. The role of calcium-dependent inactivation in defining the calcium sensitivity of sea urchin egg secretory vesicle exocytosis in vitro was examined. The cessation of fusion in the continued presence of calcium was not due to calcium-dependent inactivation. Rather, the calcium sensitivity of individual vesicles within a population of exocytotic vesicles is heterogeneous. Any specific calcium concentration above threshold triggered subpopulations of vesicles to fuse and the size of the subpopulations was dependent upon the magnitude of the calcium stimulus. The existence of multiple, stable subpopulations of vesicles is consistent with a fusion process that requires the action of an even greater number of calcium ions than the numbers suggested by models based on the assumption of a homogeneous vesicle population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.