ArticleThe Journal of general physiology1998
Na+-dependent Ca2+ extrusion governs response recovery in frog olfactory receptor cells.
Article in The Journal of general physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 110 citations in OpenAlex.
- The CaThe Journal of physiology · 2024Article
- Segregation of Ca2+ signaling in olfactory signal transduction.The Journal of general physiology · 2023Article
- Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
- Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics.Frontiers in cellular neuroscience · 2021Review
- Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Regulation and Function of Calcium in the Cilium.Current opinion in physiology · 2020Article
- Second messenger molecules have a limited spread in olfactory cilia.The Journal of general physiology · 2018Article
- TheFrontiers in cellular neuroscience · 2018Article
- The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017Review
- Tracking of unfamiliar odors is facilitated by signal amplification through anoctamin 2 chloride channels in mouse olfactory receptor neurons.Physiological reports · 2017Article
- Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Smelling better with chloride.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cyclic-nucleotide-gated cation current and Ca2+-activated Cl current elicited by odorant in vertebrate olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Dynamic dendritic compartmentalization underlies stimulus-specific adaptation in an insect neuron.Journal of neurophysiology · 2015Article
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- Article
- Ca2+-activated Cl- channels of the ClCa family express in the cilia of a subset of rat olfactory sensory neurons.PloS one · 2013Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To study the mechanism by which Ca2+, which enters during the odor response, is extruded during response recovery, recordings were made from isolated frog olfactory receptor cells using the suction pipette technique, while superfusing the olfactory cilia with solutions of modified ionic composition. When external Na+ was substituted with another cation, the response to odor was greatly prolonged. This prolongation of the response was similar irrespective of whether Na+ was replaced with Li+, which permeates the cyclic nucleotide-gated conductance, or choline, which does not. The prolonged current was greatly reduced by exposure to 300 microM niflumic acid, a blocker of the calcium-activated chloride channel, indicating that it is carried by this conductance, and abolished if Ca2+ was omitted from the external solution, demonstrating that Ca2+ influx is required for its generation. When the cilia were exposed to Na+-free solution after odor stimulation, the recovery of the response to a second stimulus from the adaptation induced by the first was greatly reduced. We conclude that a Na+-dependent Ca2+ extrusion mechanism is present in frog olfactory cilia and that it serves as the main mechanism that returns cytoplasmic Ca2+ concentration to basal levels after stimulation and mediates the normally rapid recovery of the odor response and the restoration of sensitivity after adaptation.
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