ReviewCanadian family physician Medecin de famille canadien1998
Managing acute osteoporotic vertebral fractures with calcitonin.
Review in Canadian family physician Medecin de famille canadien, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The efficacy of conservative treatment of osteoporotic compression fractures on acute pain relief: a systematic review with meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Pooled it
- Calcitonin for treating acute and chronic pain of recent and remote osteoporotic vertebral compression fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Pooled it
- Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: a systematic review of randomized, controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Pooled it
- Surgical Stabilization of the Spine: A Clinical Review of Spinal Fractures, Spondylolisthesis, and Instrumentation Methods.Journal of clinical medicine · 2025Review
- Salmon calcitonin: a review of current and future therapeutic indications.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Review
- Pharmacological treatments for persistent non-malignant pain in older persons.Drugs & aging · 2004Review
- Pain in nursing home residents: management strategies.Drugs & aging · 2001Review
- Comparing oral analgesia.Canadian family physician Medecin de famille canadien · 1999Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo inform family physicians of current issues in the management of acute vertebral fractures and to examine the evidence specifically supporting a role for calcitonin in ameliorating pain. QUALITY OF EVIDENCE: Recommendations for use of calcitonin were based primarily on a MEDLINE review of the literature for randomized, double-blind, placebo-controlled trials. The MEDLINE search was conducted from 1966 to the present using key words calcitonin, osteoporosis, pain, and vertebral fracture. Additional studies were identified by searching bibliographies of review articles. Eight trials were identified, and the conclusions drawn were based on data reported in all eight trials. MAIN
findingsSeveral randomized, placebo-controlled studies demonstrated that calcitonin had a rapid onset and a strong analgesic effect on patients with acute vertebral fractures. Nasal and subcutaneous administration were both beneficial. Pain relief occurred within the first 2 weeks, could continue for at least 4 months, and might occur if treatment were instituted any time within the first year after fracture. Side effects were generally inconvenient rather than serious.
conclusionsCalcitonin in a dose of 50 to 100 IU daily, given subcutaneously or intranasally, should be offered to all patients with serious pain related to acute vertebral fractures for symptom relief and to facilitate mobilization.
Indexed as
Identifiers
9805171PMC2277945W58347639What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.