ReviewBrain pathology (Zurich, Switzerland)1998
Mouse models of myelin diseases.
Review in Brain pathology (Zurich, Switzerland), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- Comparative Sensitivity of MRI Indices for Myelin Assessment in Spinal Cord Regions.Tomography (Ann Arbor, Mich.) · 2025Article
- Clemastine effects in rat models of a myelination disorder.Pediatric research · 2018Article
- Inherited and acquired disorders of myelin: The underlying myelin pathology.Experimental neurology · 2016Review
- Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system.Biochimica et biophysica acta · 2016Article
- Modeling the natural history of Pelizaeus-Merzbacher disease.Neurobiology of disease · 2015Article
- Article
- Misalignment of PLP/DM20 transmembrane domains determines protein misfolding in Pelizaeus-Merzbacher disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.PLoS genetics · 2011Article
- Using temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo.Methods in enzymology · 2011Article
- Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Myelin biogenesis: vesicle transport in oligodendrocytes.Neurochemical research · 2002Review
- Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene.The Journal of cell biology · 2002Article
- Role of immune cells in animal models for inherited neuropathies: facts and visions.Journal of anatomy · 2002Review
- P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves.The Journal of cell biology · 2000Article
- Transgenic models of neurodegeneration. Neurodegeneration: of (transgenic) mice and men.Brain pathology (Zurich, Switzerland) · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dys- and demyelination are the common endpoints of several inherited diseases of glial cells, which elaborate myelin and which maintain the myelin sheath very much like an "external" cellular organelle. Whereas some of the genes that are affected by mutations appear to be glial-specific, other genes are expressed in many cell types but their defect is restricted to oligodendrocytes or Schwann cells. Many of the disease genes and their encoded proteins have been studied with the help of mouse models, and a number of different molecular pathomechanisms have emerged which have been summarized in Figure 8. Some of the new concepts in the field, which have been addressed in this review, have only emerged because similar pathomechanisms were discovered for different myelin proteins. Mouse models have clearly helped to address both, the molecular pathology of myelin diseases and the normal function of myelin genes, but as discussed in this review, these questions turned out to be very different. Despite the progress in understanding the role of the abundant myelin proteins, there also remain a number of open questions that concern, among other things, the initial axon-glia recognition, the assembly process of the myelin sheath, and the long-term interaction of axons with their myelinating glia. Finally, animal models of human neurological diseases should not be restricted to the study of pathology, but they should also contribute to the development of experimental treatments. It is encouraging that a few attempts have been made.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.